Growth hormone response to clonidine and the cortisol response to dexamethasone in depressive patients

Valdivieso, Sofía Muñoz; Duval, Fabrice; Mokrani, Marie‐Claude; Schaltenbrand, Nicolas; Castro, Juarez Oliveira; Crocq, Marc‐Antoine; Mâcher, Jean-Paul

doi:10.1016/0165-1781(95)02606-1

Cited by 27 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On day 4, an APO test (SC injection of 0.75 mg Apokinon, Laboratoires Aguettant, France) ( 10 ) and on day 8, a CLO test (0.375 mg of Catapressan ® , given orally, Laboratoires Boehringer Ingelheim, France) ( 27 ) were carried out at 9 AM, after an overnight fasting, according to the same sampling procedure. Subjects were awoken at 7 AM, and a cannula was inserted into an anterior forearm vein.…”

Section: Methodsmentioning

confidence: 99%

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: This study aimed to assess hypothalamic-pituitary dopaminergic (DA), noradrenergic (NA), thyroid (HPT), and adrenal (HPA) activity in schizophrenia, in schizoaffective disorder, and in bipolar disorder. Method: We investigated a combined approach of hormone responses to (1) apomorphine (APO), a short-acting DA receptor agonist which decreases prolactin secretion (PRL), and stimulates secretion of growth hormone (GH), adrenocorticotropin (ACTH), and cortisol; (2) clonidine (CLO), an alpha 2-adrenoceptor agonist which stimulates GH secretion; (3) 8 AM and 11 PM protirelin (TRH) which stimulates thyrotropin (TSH) secretion; and (4) dexamethasone which suppresses cortisol secretion, in 13 hospitalized healthy male controls and 39 untreated male inpatients: 13 with DSM-IV paranoid schizophrenia, 13 with DSM-IV schizoaffective disorder (bipolar subtype, depressed at the time of the study), and 13 with DSM-IV bipolar disorder (depressed). Results: Compared to controls, paranoid schizophrenic patients showed (1) lower APOinduced ACTH and cortisol stimulation, and (2) higher post-dexamethasone cortisol values. Compared to controls, schizoaffective and bipolar patients showed (1) lower DDTSH values (i.e., difference between 11 PM and 8 AM TRH-TSH responses), (2) lower APO-induced PRL suppression, (3) lower CLO-induced GH stimulation, and (4) higher post-dexamethasone cortisol values. Conclusions: Although results must be interpreted with caution because of the small sample, this preliminary study suggests that depressed bipolar and schizoaffective patients share common biological dysregulations, distinct from that of paranoid schizophrenic patients. From a pathophysiological viewpoint, paranoid schizophrenic patients can be characterized by hyposensitivity of the hypothalamic DA receptors (possibly resulting from an increase in presynaptic DA release) associated with increased HPA axis activity, while depressed bipolar and schizoaffective patients can be characterized by hyposensitivity of the pituitary TRH and DAD 2 receptors (possibly linked

show abstract

Section: Methodsmentioning

confidence: 99%

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Stimulatory tests of GH secretion have shown more conclusive results. Adults with major depressive disorder exhibit a blunted GH response after the administration of GH agonists, including clonidine, levodopa, and growth hormone-releasing hormone (GHRH) [76][77][78]. These agents are thought to act via the hypothalamic, noradrenergic, and serotonergic receptors stimulating GHRH from the hypothalamus, thereby triggering GH secretion from the pituitary gland.…”

Section: Growth Hormonementioning

confidence: 99%

The roots of depression in adolescent girls: Is menarche the key?

Born¹,

Shea²,

Steiner

2002

Curr Psychiatry Rep

View full text Add to dashboard Cite

Before adolescence, the rates of depression are similar in girls and boys (or are slightly higher in boys). Yet with the onset of puberty, the gender proportion of depression dramatically shifts to a two girls to one boy ratio. What, then, is the relationship between menarche and the onset of major depression in early adolescence? Recent literature intimates that vulnerability to depression may be rooted in an intricate meld of genetic traits, normal female hormonal maturational processes, and gender socialization. Information regarding gender differences in the presentation of depressive symptoms is provided along with biologic, psychologic, and sociologic factors contributing to depression in adolescent girls. The burden of illness associated with onset of depression after menarche reinforces the importance of prevention or else expeditious recognition and intervention.

show abstract

“…Many studies have reported a persistent hypo-a2-adrenoreceptor functioning during and after withdrawal as assessed by a blunted growth hormone (GH) response to clonidine [62 -64]. GH response to clonidine is also known to be impaired in endogenous depression [65,66] as well as in panic disorder [67,68]. Impaired a2-adrenoreceptor function might therefore be hypothesized to be responsible for anxiety and depressive symptoms occurring during alcohol withdrawal.…”

Section: Noradrenergic Systemmentioning

confidence: 99%

Alcohol and withdrawal: from animal research to clinical issues

Witte

Pinto

Ansseau

et al. 2003

Neuroscience & Biobehavioral Reviews

173

109

View full text Add to dashboard Cite

The withdrawal syndrome in alcohol-dependent patients appears to be a major stressful event whose intensity increases with repetition of detoxifications according to a kindling process. Disturbances in the balance between excitatory and inhibitory neural processes are reflected in a perturbed physical state while disturbances in the balance between positive and negative reinforcements are reflected in a perturbed mood state. Our purpose is to link the different behavioral outcomes occurring during withdrawal with specific biological brain mechanisms from the animal to the human being. Better understanding of the various biological mechanisms underlying withdrawal from alcohol will be the key to design and to apply appropriate pharmaceutical management, together with appropriate therapy aimed at inducing protracted abstinence.

show abstract

Growth hormone response to clonidine and the cortisol response to dexamethasone in depressive patients

Cited by 27 publications

References 50 publications

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

The roots of depression in adolescent girls: Is menarche the key?

Alcohol and withdrawal: from animal research to clinical issues

Contact Info

Product

Resources

About