Growth hormone response to clonidine unchanged by chronic clorgyline treatment

Siever, Larry J.; Insel, Thomas R.; Roy, Benjamin F.; Murphy, Dennis L.; Uhde, Thomas W.

doi:10.1016/0165-1781(92)90086-i

Cited by 33 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Matussek et al (1980) suggested that these results indicate that the blunted growth hormone response in schizoaffective disorders may be an indication that this disorder is more closely related to endogenous depression and affective disorders than to schizophrenia. The blunted growth hormone response to clonidine in depression compared to schizophrenia has also been observed by Checkley, Slade, and Shur (1981), Siever et al (1982aSiever et al ( , 1982b, Charney, Heninger, andCharney et al (1982). Further studies of the clonidineinduced increase in growth hormone in schizoaffective depressed patients are clearly indicated.…”

Section: Effect Of Clonidine On Plasma Mhpg Blood Pressure and Growthsupporting

confidence: 56%

Biological Studies of Schizoaffective Disorders

Meltzer

Arora

Metz

1984

Schizophrenia Bulletin

View full text Add to dashboard Cite

Biological studies of the relationships between the schizoaffective disorders, the affective disorders, and schizophrenia suggest that no simple reductionist model is supported by currently available data. Thus, both affective and schizoaffective patients but not schizophrenics, manifest abnormalities such as decreased platelet serotonin (5-HT) uptake, blunted clonidine-induced increase in serum growth hormone, shortened latency of rapid eye movement (REM) sleep, and increased REM density. However, there are some types of studies which show greater similarity between schizoaffective and schizophrenic patients than between schizoaffectives and affectives--e.g., increased cerebrospinal fluid (CSF) norepinephrine levels, increased platelet 5-HT content, and decreased prostaglandin E1-stimulated adenylate cyclase activity. Other types of studies show abnormalities common to all three groups of psychoses--e.g., eye tracking dysfunction, elevated CSF concentration of gamma-aminobutyric acid, and neuromuscular abnormalities. There are also abnormalities that have been reported to be present in only one type of the psychoses. Although none of these findings have been so unequivocally demonstrated that they can be considered to be firmly established, they do suggest that it is premature to conclude that the schizoaffective disorders are subtypes of the affective disorders. The possibility of a continuum model of the psychiatric psychoses of unknown etiology merits further consideration. Further biological studies of a broad range of psychiatric psychoses with inclusion of the schizoaffective categories appear indicated.

show abstract

Section: Effect Of Clonidine On Plasma Mhpg Blood Pressure and Growthsupporting

confidence: 56%

Biological Studies of Schizoaffective Disorders

Meltzer

Arora

Metz

1984

Schizophrenia Bulletin

View full text Add to dashboard Cite

show abstract

“…As in earlier clinical studies with desipramine (Charney et al 1982b), amitriptyline (Charney et al 1982b(Charney et al , 1983, clorgyline (Siever et al 1982a), and mianserin (Chaarney et al 1984), TRZ failed to alter the GH response to clonidine, which appears to be mediated by postsynaptic ~2 receptors (Terry and Martin 1981 ;McWilliam and Meldrum 1983). Since presynaptic e2 function is altered by some of these antidepressants, the lack of change of the GH response may reflect selectivity of antidepressant effects in different subpopulations of c~2 receptors.…”

Section: Discussionmentioning

confidence: 60%

Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

1986

View full text Add to dashboard Cite

Tricyclic antidepressant drugs reduce the sensitivity of alpha 2 adrenoceptors during long-term treatment. In the present study, the alpha 2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic alpha 2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in alpha 2 adrenoceptor sensitivity.

show abstract

“…Since different groups (Siever et al, 1982b;Charney et al, 1982b;Möller et al, 1984;Charney et al, 1984;Corn et al, time (minutes) Fig. 1.…”

mentioning

confidence: 99%

Biological Aspects of Depression

Matussek¹

1986

Psychopathology

View full text Add to dashboard Cite

Several neuroendocrine studies with the clonidine-growth hormone stimulation test show endogenous depressive patients to have a reduced GH response as compared to neurotic depressives, schizophrenics and controls. The blunted GH response to clonidine seems to be a trait marker or vulnerability factor for mono- and bipolar endogenous depression. It could be explained by a reduced postsynaptic Α2-adrenoceptor sensitivity or of structures related to them. The sensitivity of Α2-adrenoceptors is influenced by both, the endorphinergic and cholinergic systems. First results supporting this concept are presented and discussed.

show abstract

Growth hormone response to clonidine unchanged by chronic clorgyline treatment

Cited by 33 publications

References 16 publications

Biological Studies of Schizoaffective Disorders

Biological Studies of Schizoaffective Disorders

Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

Biological Aspects of Depression

Contact Info

Product

Resources

About