Growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (BALB/c), tilapia ( Oreochromis niloticus ) and African catfish ( Clarias gariepinus )

Growth hormone secretagogue peptide A233 upregulates Mx expression in teleost fish in vitro and in vivo

“…Further studies should be conducted to evaluate the effect of A233 treatment in challenge trials. The results obtained in the present work with IgM stimulation are in agreement with previous studies conducted in tilapia, where the growth hormone secretagogue peptide-6 stimulated IgM levels in serum when administrated with different antigens (Martínez et al, 2017).…”

Growth Hormone Secretagogue Peptide-6 Modulates Antimicrobial Activities in Tilapia (Oreochromis sp.) Challenged with Edwardsiella tarda

“…Previously, it has been demonstrated that GHRP-6 is a growth hormone secretagogue that improve different innate and adaptive immune system parameters in aquatic organisms [7,8,19]. More recently, we provided new evidence of a direct link between GHRP-6 treatment and enhanced antimicrobial peptides transcription in tilapia [20].…”

“…GHS-R is expressed predominantly in the brain and pituitary gland, and in immune system cells from mammals and fish, suggesting a relation between ligands for these receptors and the immune system [6]. Growth Hormone-Releasing Peptide 6 (GHRP-6) is a six amino acid synthetic peptide with demonstrated stimulatory effects on innate and adaptive immune system in teleost fish [7,8]. The aim of this study was to assess the antimicrobial effects of GHRP-6 against bacterial infection in tilapia, as well as to measure gene expression of some immune-related genes before and after E. tarda infection.…”