Growth Hormone Releasing Hormone: Behavioral Evidence for Direct Central Actions

Vaccarino, Franco J.; Kennedy, Sidney H.

doi:10.1007/978-1-4612-2396-2_20

Cited by 4 publications

(7 citation statements)

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“…Thus the effect of GHRH in peripheral is also different between chicks and rodents as well as the central nervous system (Imaki et al, 1985;Vaccarino et al, 1985;Vaccarino, 1990;Tachibana et al, 2015). However, there remained a possibility that GHRH47 might induce abnormal behavior such as sleeping in chicks, and thereby inhibit feeding behavior as the side effect.…”

Section: Discussionmentioning

confidence: 99%

“…The physiological role of GHRH is thought not to be limited in the release of GH, because GHRH receptor mRNA is widely expressed within the hypothalamus of rats (Takahashi et al, 1995). In fact, brain GHRH is related to the regulation of feeding behavior because intracerebroventricular (ICV) injection of GHRH facilitates feeding behavior in rats (Vaccarino et al, 1985;Vaccarino, 1990). However, the ICV injection of GHRH suppresses feeding behavior in rats at a higher dose (Imaki et al, 1985), suggesting that the effect of GHRH on feeding behavior depends on the dose.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, GHRH-or its receptor-immunoreactive cells are also found in several peripheral organs such as small intestine, kidney, liver and lung (Christodoulou et al, 2006). Intraperitoneal (IP) injection of GHRH had no effect on food intake in rats (Vaccarino, 1990), however, consecutive subcutaneous injection of GHRH decreases food intake in 24-month-old LOU rats while it had no effect in 11-, 19-, and 28-month-old LOU rats (Veyrat-Durebex et al, 2001). Thus, the role of peripheral GHRH on the regulation of feeding seems to be complex and remains to be studied.…”

Section: Introductionmentioning

confidence: 99%

“…Similar to rodents, GHRH, GHRH-LP and their receptors mRNA have been identified in the several peripheral organs including small intestine in chickens (Wang et al, 2007;2010). Although IP injection of GHRH does not alter food intake in rats (Vaccarino, 1990), there is the possibility that this peptide may affects feeding behavior in chicks because central injection of GHRH showed opposite effect (Tachibana et al, 2015). However, the physiological roles of peripheral GHRH on feeding regulation have not been investigated yet in chickens.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

et al. 2015

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Growth hormone-releasing hormone (GHRH), a stimulator of growth hormone (GH) secretion, is known to have several physiological roles such as the regulation of feeding behavior in mammals. Recently, we have reported that central injection of chicken GHRH decreased food intake in chicks, however, its peripheral role on feeding behavior has not been clarified. The purpose of the present study was to investigate the effect of peripheral injection of GHRH on feeding behavior in chicks (Gallus gallus). Intraperitoneal (IP) injection of GHRH47 (1 nmol), full length form of chicken GHRH significantly decreased food intake in chicks although the injection of GHRH27 and GHRH27-NH 2 , short forms of chicken GHRH had no effect. The IP injection of GHRH47 did not induced any abnormal behavior, suggesting that GHRH47-induced anorexia might not be related to abnormal behavior such as sleeping, hyperactivity and convulsion. The anorexigenic effect of GHRH47 seemed not to be related to GH because IP injection of bovine GH did not affect feeding behavior in chicks. Collectively, these results suggest that peripheral GHRH is related to inhibit feeding behavior in chicks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

et al. 2015

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“…For example, growth hormone-releasing hormone (GHRH) facilitates feeding behavior in mammals [29,30] but suppresses feeding in chicks [31]. In contrast, prolactin-releasing peptide (PrRP) suppresses feeding behavior in rats [32,33] but increases feeding in chicks [34].…”

Section: Discussionmentioning

confidence: 99%

Effects of Neurotensin and LANT-6 on Food Intake in Chicks

Masuda¹

2015

AJLS

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Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT [8][9][10][11][12][13] ; are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks.

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Central regulation of food intake in the neonatal chick

Furuse

2002

Animal Science Journal

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Regulating food intake is complicated in animals including domestic birds. Just after hatching, neonatal chicks find their food by themselves and they can control food intake, since domestic chicken belongs to the precocial type of avian species. Thus, domestic chickens have relatively well‐developed mechanisms of food‐intake control at hatching. While many aspects of food‐intake regulation in chickens appear similar to that in mammals, there are some responses that are unique to chickens. For instance, some neurotransmitters such as neuropeptide Y (NPY), orexin‐A, orexin‐B, motilin, melanin‐concentrating hormone (MCH), galanin, growth hormone releasing factor (GRF) and ghrelin stimulate feeding in mammals. Only NPY strongly stimulates food intake in birds similar to that observed in mammals; however, both orexins, motilin, MCH and galanin failed to alter food intake of the chick. Moreover, GRF and ghrelin suppressed feeding of chicks. On the other hand, cholecystokinin (CCK), gastrin, glucagon‐like peptide‐1 (GLP‐1), corticotropin‐releasing factor (CRF), histamine, α‐melanocyte stimulating hormone (α‐MSH), leptin and bombesin are known to suppress feeding in mammals. These responses are similar to those of mammals except for leptin. Therefore, the inhibitory mechanisms for feeding are well conserved in chicks.

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Growth Hormone Releasing Hormone: Behavioral Evidence for Direct Central Actions

Cited by 4 publications

References 45 publications

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

Effects of Neurotensin and LANT-6 on Food Intake in Chicks

Central regulation of food intake in the neonatal chick

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