Growth hormone-releasing factor (GRF) induced growth hormone advances puberty in female buffaloes

Haldar, Avijit; Prakash, B.S.

doi:10.1016/j.anireprosci.2005.06.002

Cited by 8 publications

(7 citation statements)

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“…We have already reported that the treatment with exogenous GRF augmented growth and advanced puberty onset in association with the temporal hormonal changes in buffalo heifers (Haldar and Prakash, 2006). In the present study, we attempted to explore the effect of GRF on blood metabolites and minerals assuming whether GRF‐induced GH could have any relationship with those parameters in the process of puberty onset in late maturing buffalo heifers.…”

Section: Discussionmentioning

confidence: 91%

“…However, one of the bitter criticisms against the Indian buffalo breeds is the late sexual maturity. Recently, exogenous administration of growth‐hormone‐releasing factor (GRF) has been reported to augment growth and advance puberty onset (Haldar and Prakash, 2006) in buffalo heifers. Exogenous GRF directly acts on somatotrophs of adenohypophysis for the synthesis and release of GH (Spencer, 1985), which basically takes part in intermediary metabolism for growth promotion process either directly at tissue level or through the release of insulin‐like growth factor‐I (Breier and Gluckman, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Effect of exogenous growth‐hormone‐releasing factor on blood metabolites and minerals in late maturing buffalo heifers (Bubalus bubalis)

Haldar

Prakash

2007

Animal Physiology Nutrition

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Previous studies have suggested that growth-hormone-releasing factor (GRF) enhanced growth and advanced puberty onset along with hormonal changes in buffalo heifers (Bubalus bubalis). However, it is not known to what extent exogenous GRF could influence blood metabolites and minerals to bring about puberty in buffalo heifers. Therefore, we planned to investigate the effect of exogenous bovine GRF (bGRF) on blood metabolites and minerals in buffalo heifers during a 3-month pre-treatment period, 9-month treatment period and 1-month post-treatment period. Six buffalo heifers were treated intravenously with bGRF (10 mug per 100 kg body weight) at 15-day interval for 9 months. Another six buffalo heifers of weight- and age-matched received requisite amount of vehicle (0.9% NaCl solution) during the same period. Exogenous bGRF enhanced (p < 0.01) plasma non-esterified fatty acids (NEFA) concentrations in treatment group when compared with control group during the treatment and post-treatment period, while plasma alpha-amino nitrogen (AAN) concentrations showed a decreasing trend (p < 0.05) in the treatment group when compared with the control group during the treatment and post-treatment periods. The plasma inorganic phosphorus (Pi) was found to be higher (p < 0.05) in the treatment group animals in comparison with the levels recorded in the control group animals during the treatment as well as post-treatment periods. However, there was no change (p > 0.05) in plasma glucose and calcium concentrations between the two groups. Plasma NEFA was found to be positively correlated with plasma growth hormone (GH); however, it was only significant for the treatment group (r = + 0.76; p < 0.05). Plasma AAN in the treatment group exhibited negative correlation with plasma GH (r = 0.72; p < 0.05), while plasma AAN and GH were recorded to be positively correlated in the control group (r = 0.47; p < 0.05). The present findings suggest that exogenous bGRF induces GH release that increases plasma NEFA and Pi and decreases AAN concentrations, which probably help to reach a certain physiological state that initiates events necessary for bringing about puberty in buffalo heifers.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of exogenous growth‐hormone‐releasing factor on blood metabolites and minerals in late maturing buffalo heifers (Bubalus bubalis)

Haldar

Prakash

2007

Animal Physiology Nutrition

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“…The attainment of puberty is defined as the fine adjusting of central and local endocrine balance and its relationship to the cellular events taking place in the organs of the reproductive tract. In buffaloes a close association between the growth hormone and LH in the mechanism of puberty has been highlighted (Haldar and Prakash 2006), and their parallel highest concentrations were recorded just 1 month before puberty (Haldar and Prakash 2005). A comparison of follicle development within waves in puberal and pluriparous buffaloes has been studied by Presicce et al.…”

Section: Female Reproductive Function and Assisted Reproductive Technmentioning

confidence: 99%

Reproduction in the Water Buffalo

Presicce

2007

Reprod Domestic Animals

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In this paper, an account of various aspects related to buffalo reproduction are given. Fundamental concepts of the reproductive physiology as well as manipulation of the reproductive function will be presented. This will include an overview of the most recent developments of the oestrous cycle and the ovulation control, new strategies of reproductive management for the improvement of genetic gain and the application of newly developed reproductive technologies, such as in vitro embryo production, embryo and sperm sexing and cloning.

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“…Synchronization by double prostaglandin needs a regular cyclic activity of the animals, as demonstrated by the evidence that anoestrus or prepubertal subjects are not responsive (Stevenson and Pursley, 1994). After the onset of puberty, LH decreased at a level similar to that of 4 months before puberty and a positive correlation between LH and body weight was found during the prepubertal period (Haldar and Prakash, 2006). On the contrary, the LBW did not affect the ovulation rate in animals synchronized by O-TAI Program.…”

Section: Discussionmentioning

confidence: 99%

Effect of live body weight and method of synchronization on ovulation, pregnancy rate and embryo and fetal loss in buffalo heifers

et al. 2019

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This study aimed to assess the influence of live body weight (LBW) and age on reproductive performance in buffalo heifers synchronized by different treatments.The study was carried out on 146 Mediterranean buffalo heifers (mean age 25.3±13.4 months, LBW 424±47 kg), divided into 2 homogeneous groups and synchronized by Ovsynch-TAI Program (OVS; n = 72) or double prostaglandin administered 12 days apart (PGF; n = 74). All the buffaloes were inseminated twice and follicle dimensions and ovulation rate (OR) were assessed by ultrasound 24 and 48 h post-insemination. Pregnancy was assessed on day 25, 45 and 90 post-insemination and the incidence of late embryonic (LEM) and fetal (FM) mortality were respectively recorded. Data were analyzed by ANOVA, Chi-square test and multiple logistic regression. The LBW was significantly (P<0.05) higher in inseminated animals, compared to those that did not respond to the treatments (450.0±3.2 vs. 423.2±9.6 kg in inseminated and not inseminated heifers, respectively). Total OR was similar between groups, although OR at 24 h tended to be higher (P = 0.06) in OVS (86.7 vs. 72.9% in OVS and PGF, respectively). A (P<0.01) higher LBW was observed in ovulated heifers of PGF, while no differences were recorded in OVS. LBW affected OR (odds ratio = 1,032; P<0.05) only in PGF, while no effects were recorded in OVS. Total pregnancy rate, LEM and FM were similar between groups. In conclusion, the LBW would be considered before including buffalo heifers in a synchronization program and both synchronization treatments can be useful.

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Growth hormone-releasing factor (GRF) induced growth hormone advances puberty in female buffaloes

Cited by 8 publications

References 55 publications

Effect of exogenous growth‐hormone‐releasing factor on blood metabolites and minerals in late maturing buffalo heifers (Bubalus bubalis)

Effect of exogenous growth‐hormone‐releasing factor on blood metabolites and minerals in late maturing buffalo heifers (Bubalus bubalis)

Reproduction in the Water Buffalo

Effect of live body weight and method of synchronization on ovulation, pregnancy rate and embryo and fetal loss in buffalo heifers

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