Growth Hormone Release in Response to Growth Hormone-Releasing Hormone in Term and Preterm Neonates

Lanes, Roberto; Nieto, C. G.; Bruguera, Carlos; Moncada, Gustavo; Moret, Luis A; Lifshitz, Fima

doi:10.1159/000243131

Cited by 7 publications

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References 12 publications

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“…In a number of mammalian species the circulating growth hormone (GH) concentrations are dramatically higher in fetuses than in adults (human: Lanes et al. 1989; bovine: Coxam et al.…”

Section: Growth Hormonementioning

confidence: 99%

Neuroendocrine Regulation of Growth Hormone and Luteinizing Hormone in Fetal and Neonatal Pig

Parvizi¹,

Ellendorff²,

Elsaesser³

2001

Reprod Domestic Animals

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Ontogeny of the production and the regulation of growth hormone and Luteinizing hormone is studied in a series of experiments utilizing male and female pigs at different fetal and neonatal stages. Growth hormone mRNA is detectable in both sexes as early as d. 50 p.c. The mRNA levels increase to reach the maximum levels at d. 95-110 p.c. Plasma levels of GH follow the developmental patterns of GH mRNA. A sex difference is evident around d. 80-90 p.c. with males having higher GH levels than females. The stimulatory but not the inhibitory mechanisms of GH secretion are fully functioning in the pig fetus. LHbeta mRNA is detectable earlier in females (d. 50 p.c.) than in males (d. 65 p.c.). Plasma concentrations of LH increase with fetal age in female fetuses, but in male fetuses there is no distinct developmental pattern evident. Basal LH secretion achieves maximum levels in both sexes after birth. Opioids do modulate fetal LH secretion, however, the mode of their action is age-dependent.

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“…In a number of mammalian species the circulating growth hormone (GH) concentrations are dramatically higher in fetuses than in adults (human: Lanes et al. 1989; bovine: Coxam et al.…”

Section: Growth Hormonementioning

confidence: 99%

Neuroendocrine Regulation of Growth Hormone and Luteinizing Hormone in Fetal and Neonatal Pig

Parvizi¹,

Ellendorff²,

Elsaesser³

2001

Reprod Domestic Animals

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Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2, p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma

et al. 1996

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Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in >25% in I 2 I (4 I YO) cases. PCNA accumulation was related to over-expression of c-erbB-2 and p53 and tended to be increased in cases with ras over-expression. PCNA expression was identical in primary and corresponding metastases. No significant relationship was observed between PCNA expression and prognosis and other clinico-pathological variables, including grade of differentiation, growth pattern, Dukes' stage, site, age or sex. We conclude that PCNA expression may be related to alterations of oncoproteins but that PCNA itself could not provide additional information for the development of metastasis and prognosis in colorectal adenocarcinoma.o 1996 Wiley-Liss, Inc.Proliferating cell nuclear antigen (PCNA) is a 36-kDa nuclear protein and a marker of cell proliferation, which progressively accumulates in late GI and early S phases and disappears at the end of mitosis. It acts as an auxiliary protein of the DNA polymerase delta essential for the processive activity of this enzyme in cells entering S phase (Lane, 1989). The ras gene family consists of H-ras, K-ras and N-ras genes and codes for 21-kDa proteins, which are located on the inner surface of the plasma membrane (Barbacid, 1987). The proteins possess intrinsic GTPase activity and participate in the transduction of signals across the cell membrane (Barbacid, 1987). The c-erbB-2 gene encodes a transmembrane protein with strong sequence homology to the epidermal growth factor receptor; thus, this protein has been postulated to be a receptor for some growth factors (Maguire and Greene, 1989). p53 is a nuclear phosphoprotein and regulates cellular growth and differentiation (Lane, 1989). Since these oncoproteins are implicated in cellular proliferation, they may be related to PCNA. However, there is little information on the correlation of PCNA with these oncoproteins in colorectal tumours. The results concerning the relationship between PCNA expression ;and clinico-pathological parameters or prognosis of colorectal cancers are conflicting (Al-Sheneber et al., 1993;Linden et al., 1993;Mayer et al., 1993;Lazaris et al., 1994;Teixeira et al., 1994;Willett et al., 1994). Therefore, in this large series of colorectal adenocarcinomas, we have analysed the relationship between PCNA expression and ras, c-erbB-2, p53, clinicopathological parameters as well as survival using immunohistochemistry. PATIENTS AND METHODS Patients and pathological dataTwo hundred and ninety-three patients with primary colorec-1.al adenocarcinoma diagnosed at the Department of Pathology, University Hospital of Linkoping, were consecutively collected from 1972 to 1986. Among them, regional lymph nodes with metastasis from 56 patients were obtained. No patient had received pre-operative radiotherapy or ...

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Normal and Aberrant Growth

Cooke¹,

DiVall²,

Radovick³

2011

Williams Textbook of Endocrinology

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Growth Hormone Release in Response to Growth Hormone-Releasing Hormone in Term and Preterm Neonates

Cited by 7 publications

References 12 publications

Neuroendocrine Regulation of Growth Hormone and Luteinizing Hormone in Fetal and Neonatal Pig

Neuroendocrine Regulation of Growth Hormone and Luteinizing Hormone in Fetal and Neonatal Pig

Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2, p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma

Normal and Aberrant Growth

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