Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver

Eleswarapu, Satyanarayana; Jiang, Honglin

doi:10.1677/joe.1.05821

Cited by 21 publications

(24 citation statements)

References 46 publications

(57 reference statements)

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“…It has been shown with conflicting results that the expression of C/EBPa mRNA in mammals is regulated by GH (Vidal et al 1997, Rastegar et al 2000a,b, Strand et al 2000, Eleswarapu & Jiang 2005. In our study, we showed that, although the expressions of C/EBPa in the rainbow trout liver and in RTH cells are not responsive to induction by GH, the level of C/EBPa mRNA decreased in adult fish at 6 h post GH injection.…”

Section: Discussionsupporting

confidence: 40%

Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein genes and their responses to induction by GH in vitro and in vivo

Chiou²,

Lin³

et al. 2007

Journal of Endocrinology

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CCAAT/enhancer-binding proteins (C/EBPs) are transcription factors consisting of six isoforms and play diverse physiological roles in vertebrates. In rainbow trout (Oncorhynchus mykiss), in addition to the reported C/EBPb1, we have isolated cDNA of four other isoforms, C/EBPa, C/EBPb2, C/EBPd1, C/EBPd2, from the liver. Comparison of the deduced amino acid sequence of rainbow trout C/EBPs with those of other vertebrates revealed that C/EBP isoforms are highly conserved. The profiles of tissue-specific expression of individual C/EBP isoform mRNA, determined by quantitative real-time (RT)-PCR showed distinct patterns. Furthermore, injection of bovine GH into yearling rainbow trout resulted in a significant increase of mRNA levels of C/EBPb1,

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Section: Discussionsupporting

confidence: 40%

Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein genes and their responses to induction by GH in vitro and in vivo

Chiou²,

Lin³

et al. 2007

Journal of Endocrinology

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“…on d0, d7, d56, and d63). The liver biopsy was performed as described previously (Eleswarapu & Jiang 2005). Blood samples were allowed to clot, and were centrifuged to separate the serum.…”

Section: Animals Treatments and Sample Collectionmentioning

confidence: 99%

“…The PCR was run on an Applied Biosystems 7300 Real-Time PCR System (Applied Biosystems) under the following conditions: 50 8C for 2 min, 95 8C for 10 min, and 40 cycles of 95 8C for 15 s and 60 8C for 1 min. The PCR data were analyzed using GAPDH mRNA as an internal control, the expression of which in bovine liver is not affected by nutritional level or GH treatment based on our previous studies (Wang et al 2003, Eleswarapu & Jiang 2005.…”

Section: Real-time Reverse Transcription-pcrmentioning

confidence: 99%

Effect of feeding level on serum IGF1 response to GH injection

Hall²,

Akers³

et al. 2010

Journal of Endocrinology

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This study was conducted to further understand the mechanism by which nutrition modulates GH-induced changes in serum IGF1 concentration in cattle. Cows were fed hay only or corn-based concentrates in addition to hay for 8 weeks. At week 8, serum concentrations of IGF1, IGF-binding protein 3 (IGFBP3), and acid-labile subunit (ALS) as well as their mRNA levels in liver were determined immediately before and 7 days after an injection of GH formulated for sustained release. GH injection caused greater increases in both serum IGF1 concentration and liver IGF1 mRNA expression in the cows fed concentrates than in those fed hay. In the cows fed concentrates, the magnitude of the GH-induced increase in serum IGF1 concentration was, however, much greater than that in liver IGF1 mRNA expression. This difference was not due to GH-induced IGF1 mRNA being translated more efficiently. GH injection also induced greater increases in serum IGFBP3 and ALS concentrations in the cows fed concentrates than fed hay. The injection, however, did not induce a greater increase in IGFBP3 or ALS mRNA in the cows fed concentrates than fed hay. These data and the fact that the ternary complex of IGF1/IGFBP3/ALS stabilizes each of the components in the blood suggest that in cows, increased nutrition enhances serum IGF1 response to GH not only by increasing IGF1 mRNA response to GH in the liver, but also by elevating IGFBP3 and ALS concentrations in the blood.

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“…Circadian oscillation in plasma glucose, nonesterified fatty acids, b-hydroxybutyrate and urea nitrogen have also been observed in cows (Bitman et al, 1990;Lefcourt et al, 1999). Studies carried out at the molecular level revealed that DBP mRNA expression, a clock-regulated transcription factor that directs hepatocyte metabolism (Oishi et al, 2000;Noshiro et al, 2007), showed a circadian pattern that was altered when cattle were injected with somatotropin (Eleswarapu and Jiang, 2005). These daily cycles in hormones and metabolites likely help coordinate timing of intake with metabolism.…”

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confidence: 99%

Does the circadian system regulate lactation?

Plaut

Casey

2012

Animal

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Environmental variables such as photoperiod, heat, stress, nutrition and other external factors have profound effects on quality and quantity of a dairy cow's milk. The way in which the environment interacts with genotype to impact milk production is unknown; however, evidence from our laboratory suggests that circadian clocks play a role. Daily and seasonal endocrine rhythms are coordinated in mammals by the master circadian clock in the hypothalamus. Peripheral clocks are distributed in every organ and coordinated by signals from the master clock. We and others have shown that there is a circadian clock in the mammary gland. Approximately 7% of the genes expressed during lactation had circadian patterns including core clock and metabolic genes. Amplitude changes occurred in the core mammary clock genes during the transition from pregnancy to lactation and were coordinated with changes in molecular clocks among multiple tissues. In vitro studies using a bovine mammary cell line showed that external stimulation synchronized mammary clocks, and expression of the core clock gene, BMAL1, was induced by lactogens. Female clock/ clock mutant mice, which have disrupted circadian rhythms, have impaired mammary development and their offspring failed to thrive suggesting that the dam's milk production was not adequate enough to nourish their young. We envision that, in mammals, during the transition from pregnancy to lactation the master clock is modified by environmental and physiological cues that it receives, including photoperiod length. In turn, the master clock coordinates changes in endocrine milieu that signals peripheral tissues. In dairy cows, it is clear that changes in photoperiod during the dry period and/or during lactation influences milk production. We believe that the photoperiod effect on milk production is mediated, in part by the 'setting' of the master clock with light, which modifies peripheral circadian clocks including the mammary core clock and subsequently impacts milk yield and may impact milk composition.Keywords: mammary, lactation, circadian rhythm, photoperiod, metabolism ImplicationsThe circadian system coordinates internal physiological processes in mammals and synchronizes these processes to the animal's environment. We review the literature and discuss recent findings from our laboratory and others that suggest the circadian system regulates lactation, including coordinating changes in the dam's physiology needed to initiate and maintain lactation and mediating the photoperiod effect on milk production. Identification of environmental and physiological inputs that affect genes that control circadian rhythms will enable development of approaches to alter gene expression to maximize production efficiency in farm animals. IntroductionNearly all physiological and behavioral functions of animals are rhythmic including secretion patterns of hormones, sleep-wake cycle, metabolism and core body temperature.A circadian rhythm is a roughly 24-h cycle in the biochemical, physiological or behaviora...

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Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver

Cited by 21 publications

References 46 publications

Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein genes and their responses to induction by GH in vitro and in vivo

Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein genes and their responses to induction by GH in vitro and in vivo

Effect of feeding level on serum IGF1 response to GH injection

Does the circadian system regulate lactation?

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