Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression

Houseknecht, Karen L.; Portocarrero, Carla; Ji, Shaoquan; Lemenager, Racute ̃.; Spurlock, Michael E.

doi:10.1677/joe.0.1640051

Cited by 113 publications

(85 citation statements)

References 39 publications

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“…In support of the latter, insulin upregulates leptin expression in vivo and in vitro in rodent and human WAT (Saladin et al 1995, Kolaczynski et al 1996b, Boden et al 1997, and in bovine WAT explants (Houseknecht et al 2000). These effects of insulin are dependent on adequate uptake of glucose, suggesting that cellular energy availability is the primary factor regulating leptin synthesis (Mueller et al 1998, Wellhoener et al 2000.…”

Section: Discussionmentioning

confidence: 94%

“…Sustained periods of negative EB are also characterized by elevation in the plasma concentration of GH and by GH resistance in the liver, resulting in depressed plasma concentration of IGF-I (McGuire et al 1995, Kobayashi et al 1999. GH attenuates the ability of insulin and dexamethasone to stimulate leptin synthesis in bovine WAT explants (Houseknecht et al 2000), but neither GH nor IGF-I has these effects in rat adipocytes (Hardie et al 1996). Prolactin stimulates leptin synthesis in rats (Gualillo et al 1999).…”

Section: Discussionmentioning

confidence: 99%

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Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance

Block

Butler²,

Ehrhardt³

et al. 2001

Journal of Endocrinology

282

229

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Dairy cows suffer from an intense energy deficit at parturition due to the onset of copious milk synthesis and depressed appetite. Despite this deficit, maternal metabolism is almost completely devoted to the support of mammary metabolism. Evidence from rodents suggests that, during periods of nutritional insufficiency, a reduction in plasma leptin serves to co-ordinate energy metabolism. As an initial step to determine if leptin plays this role in periparturient dairy cows, changes in the plasma concentration of leptin were measured during the period from 35 days before to 56 days after parturition. The plasma concentration of leptin was reduced by 50% after parturition and remained depressed during lactation despite a gradual improvement in energy balance; corresponding changes occurred in the abundance of leptin mRNA in white adipose tissue. To determine whether negative energy balance caused this reduction in circulating leptin, cows were either milked or not milked after parturition. Absence of milk removal eliminated the energy deficit of early lactation, and doubled the plasma concentration of leptin. The plasma concentration of leptin was positively correlated with plasma concentrations of insulin and glucose, and negatively correlated with plasma concentrations of growth hormone and non-esterified fatty acids. In conclusion, the energy deficit of periparturient cows causes a sustained reduction in plasma leptin. This reduction could benefit early lactating dairy cows by promoting a faster increase in feed intake and by diverting energy from non-vital functions such as reproduction.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance

Block

Butler²,

Ehrhardt³

et al. 2001

Journal of Endocrinology

282

229

View full text Add to dashboard Cite

show abstract

“…The mechanism of this regulation is unknown in ruminant species, but could be due to an increase in the sympathetic nervous system activity in white adipose tissue, as was shown in mice (Trayhurn et al 1998) and is suggested by the negative effect of a beta-agonist infusion on cattle plasma leptin (Chilliard et al 1998a). An alternative explanation could be that the stimulation of leptin expression by insulin (Houseknecht et al 1998a) was decreased during underfeeding. This reduction in leptin production is observed whatever the body fatness of the ewes, which shows that the nutritional status per se could modulate plasma leptin in ruminants, as in monogastric animals.…”

Section: Discussionmentioning

confidence: 99%

Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep

Delavaud

Bocquier²,

Chilliard

et al. 2000

Journal of Endocrinology

354

215

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A specific leptin RIA was developed to assess concentrations of leptin in ovine plasma, and was shown to be efficient with bovine and caprine plasma. A specific, high-affinity antibody was generated against recombinant ovine leptin which, when used in a competitive leptin RIA, provided valid estimates of linearity (r=+0·989-0·998), recovery (102%), repeatability (13%) and limit of sensitivity (0·83 ng/ml for 100 µl sample size). Serial dilutions of five ovine, bovine or caprine plasma samples showed good linearity and parallelism with the recombinant ovine leptin standard curve. A comparison of this RIA was made with a commercial 'multi-species' RIA kit using 56 ovine plasma samples. Major differences were found in assay sensitivity. Non-lactating, non-pregnant, ovariectomized ewes were fed a ration for 65 days which provided 90 9% (control; n=12) or 39 2% of maintenance energy requirements (underfed; n=16) in order to analyse the respective effects of body fatness (estimated by either an in vivo dilution technique or body condition scoring) and of nutritional status on plasma leptin concentration. There was a significant positive correlation between body fatness or body condition score and plasma leptin levels (r=+0·68, P<0·001 or r=+0·72, P<0·001 respectively). When concentrations of leptin were assessed over time, underfed ewes exhibited a dramatic reduction in plasma leptin values ( 56%, P<0·001). These data provide strong evidence that, in sheep, the variations in plasma concentrations of leptin are related to variations in body fatness (35%) and, to a lesser extent, in nutritional status (17%).

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“…Wyniki dotychczas opublikowanych prac dotyczących wpływu hormonu wzrostu na sekrecję leptyny są rozbieżne [31][32][33]. W badaniach in vivo przeprowadzonych na różnych gatunkach zwierząt obserwowano zarówno brak wpływu GH na ekspresję leptyny w adipocytach [33], jak i jego działa-nie pobudzające [31] lub hamujące [32].…”

Serum leptin concentrations in adolescents and young adults with growth hormone deficiency

Oświęcimska¹,

Roczniak²,

Świętochowska³

et al. 2015

Pediatr. Endocrinol.

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Introduction. Leptin (LEP) is the first from described adipokines of pleiotropic action. Growth hormone deficiency (GHD) may contribute to the development of disturbances in the functioning of adipose tissue (AT), and many disorders observed in untreated patients with GHD coincides with the spectrum of action of leptin. Results of published papers according the effects of GH secretion on LEP are divergent. There is no data on serum LEP in a group of adolescents and young adults with varying degrees of GHD in the transition phase. Aim of the study. 1) Assessment of LEP levels in adolescents with varying degrees of GHD (severe or partial) and in the control groups with normal GH secretion and healthy. 2) Evaluation of the relationship between the degree of functional GH/IGF-1 axis impairment and LEP. 3) Analysis of the correlations between LEP and selected cardiometabolic risk factors in the group of patients with severe GHD and those with normal GH secretion. Materials and methods. Based on the current results of GH assessment during insulin tolerance test (ITT) patients Słowa kluczowe leptyna, niedobór hormonu wzrostu, okres przejścio-wy, młodzież, młodzi dorośli Streszczenie Wstęp. Leptyna (LEP) jest pierwszą opisaną adipokiną o działaniu plejotropowym. Niedobór hormonu wzrostu (GH) może przyczyniać się do rozwoju zaburzeń w funkcjonowaniu tkanki tłuszczowej (AT), a wiele zaburzeń stwierdzanych u nieleczonych osób z niedoborem GH pokrywa się ze spektrum działania LEP. Wyniki dotychczas opublikowanych prac dotyczących wpływu GH na sekrecję LEP są rozbieżne. Brakuje prac dotyczących zachowania się stężeń leptyny w grupie młodzieży i młodych dorosłych z róż-nym stopniem niedoboru GH w tzw. okresie przejściowym. Cel pracy. 1) Ocena stężeń LEP u młodzie-ży z różnym stopniem niedoboru GH (znacznym lub częściowym) oraz w grupach kontrolnych osób z prawidłowym wydzielaniem GH i zdrowych. 2) Zbadanie zależności pomiędzy stopniem upośledzenia funkcji osi GH/IGF-1 a stężeniem LEP. 3) Analiza korelacji pomiędzy stężeniami LEP a wybranymi czynnikami ryzyka kardiometabolicznego w grupie badanych ze znacznym niedoborem GH i u osób z prawidło-wą czynnością somatotropową przysadki. Materiał Stężenia leptyny w surowicy młodzieży i młodych dorosłych z niedoborem hormonu wzrostu

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Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression

Cited by 113 publications

References 39 publications

Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance

Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance

Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep

Serum leptin concentrations in adolescents and young adults with growth hormone deficiency

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