Restricted Growth - Clinical, Genetic and Molecular Aspects 2016
DOI: 10.5772/64606
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Growth Hormone Receptor Signaling Pathways and its Negative Regulation by SOCS2

Abstract: Growth hormone (GH) is a critical regulator of linear body growth during childhood but continues to have important metabolic actions throughout life. The GH receptor (GHR) is ubiquitously expressed, and deficiency of GHR signaling causes a dramatic impact on normal physiology during somatic development, adulthood, and aging. GHR belongs to a family of receptors without intrinsic kinase activity. However, GH binding to homodimers of GHR results in a conformational change in the receptors and the associated tyro… Show more

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Cited by 3 publications
(3 citation statements)
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References 115 publications
(170 reference statements)
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“…14 GH is a crucial somatic cell growth regulator through its pleiotropic effect on metabolism systemically and local bone growth plates; it is secreted by the pituitary gland that binds to receptors on the cell surface of target tissues (GHRs) which will trigger a cascade of rapid intracellular signaling. 15…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…14 GH is a crucial somatic cell growth regulator through its pleiotropic effect on metabolism systemically and local bone growth plates; it is secreted by the pituitary gland that binds to receptors on the cell surface of target tissues (GHRs) which will trigger a cascade of rapid intracellular signaling. 15…”
Section: Discussionmentioning
confidence: 99%
“…16 The family of transmembrane cytokine receptors from which GHR is derived has no intrinsic enzymatic activity; the cytoplasmic domain of GHR associates with tyrosine kinase Janus kinase 2 (JAK2) rather than activating intracellular signaling. 15 An enzyme-like receptor is a protein that passes through the membrane only once. Enzyme-linked receptors have hormone-binding sites outside the cell membrane, while on the inside are the catalytic or enzyme-binding sites.…”
Section: Discussionmentioning
confidence: 99%
“…14 GH is a crucial somatic cell growth regulator through its pleiotropic effect on metabolism systemically and local bone growth plates; it is secreted by the pituitary gland that binds to receptors on the cell surface of target tissues (GHRs) which will trigger a cascade of rapid intracellular signaling. 15 The biological role of growth hormone is to bind to the GHR, so the protein on almost every cell membrane in the body has domains of a 246 long extracellular (GH-binding) amino acid, the transmembrane, and a 350 long intracellular (cytoplasmic) amino acid. The GHR protein itself consists of a total of 638 residues.…”
Section: Discussionmentioning
confidence: 99%