Growth Hormone Levels in Protein Calorie Malnutrition

Samuel, A.M.; Deshpande, U. R.

doi:10.1210/jcem-35-6-863

Cited by 26 publications

(13 citation statements)

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“…Because of the strong correlation between GH release and plasma SmC concentration in the adult population studied, the latter level could be used as an indicator of endogenous GH status in these individuals. In subjects with undernutrition (13)(14)(15)(16)(17)(18)(19), liver disease (20,21), renal insufficiency (22,23), or hypothyroidism (33), however, SmC is not a reliable indicator of GH release. at a substantial rate until age 30, and then began to diminish.…”

Section: Discussionmentioning

confidence: 99%

“…For the RIA of SmC, intra-and inter-assay coefficients ofvariation were 6 and 10%, sensitivity was 0.1 U/ml, and cross-reaction with SmA was 3%. The second inpatient study lasted 17 d. Subjects ate a constant diet designed for metabolic balance studies of N, P, and K as described (12). Activity there were from 9 to 12 subjects in each decade from third to ninth.…”

Section: Methodsmentioning

confidence: 99%

“…Because endogenous GH release is influenced by nutritional state (13)(14)(15)(16)(17)(18)(19) and by disease (20)(21)(22)(23), we confined the study to ambulatory adults who were within 15% of ideal body weight and free of progressive or active disease.…”

Section: Introductionmentioning

confidence: 99%

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Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Rudman¹,

Kutner²,

Rogers³

et al. 1981

J. Clin. Invest.

645

290

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A B S T R A C T Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free ofactive or progressive disease. 9 to 12 individuals in each decade from third to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at halfhour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt314/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects.All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release: peak waking and sleeping seruim GH < 4 nglml; plasma SmC < 0.38 U/ ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH.Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P < 0.05). Plasma SmC < 0.38 U/ml corresponded to peak nocturnal serum GH < 4 ng/ml. The prevalence of plasma SmC < 0.38 U/ml

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Rudman¹,

Kutner²,

Rogers³

et al. 1981

J. Clin. Invest.

645

290

View full text Add to dashboard Cite

show abstract

“…When compared with those of healthy infants matched for age or size, the fasting GH levels found in untreated marasmus in the present study and others (39,44) must be considered normal, not "high." The very poor or delayed suppression is abnormal; this may be due to a poor or delayed glycemic stimulus, but this was not true in most of our cases, or in infants receiving intravenous glucose (3 1, 38, 39).…”

Section: Normal Infantsmentioning

confidence: 49%

“…This is compatible with the reports of others in marasmus (21,24,31) and in hypotrophic newborn infants (I, 29). The more normal fasting FFA found by some investigators (16,17) may have been due to differences in age or in dietary management before study; high carbohydrate feedings usually suppress elevated x SEM patients with low serum albumin, but did not specify the timing of the studies (44). Still another found relatively normal levels in six cases, only two being moderately elevated (42).…”

Section: Normal Infantsmentioning

confidence: 91%

Metabolic and Hormonal Responses to a Protein-Glucose Meal in Normal Infants and in Marasmus and Marasmic Kwashiorkor

et al. 1976

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The Physiology of eating disorders

Weiner¹

1985

Int. J. Eat. Disord.

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This article summarizes current understanding of the pathophysiology of anorexia nervosa. Evidence is reviewed of alterations in hypothalamic‐pitui‐tary‐thyroid mechanisms, catecholamine metabolism, and endogenous opioid activity. It is concluded that once weight loss and starvation occur, the usual mechanisms for release and inhibition of various regulators of eating behavior change, and a new set of regulating mechanisms is instituted. Thus, despite an increased body of knowledge, understanding of the origins of anorexia nervosa still eludes us.

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Growth Hormone Levels in Protein Calorie Malnutrition

Cited by 26 publications

References 0 publications

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

Metabolic and Hormonal Responses to a Protein-Glucose Meal in Normal Infants and in Marasmus and Marasmic Kwashiorkor

The Physiology of eating disorders

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