Growth hormone increases and insulin-like growth factor-I decreases circulating lipoprotein(a)

Abstract

We conclude that long-term GH treatment increases and IGF-I decreases circulating levels of Lp(a). These findings may have clinical relevance in view of the increasing use of hGH in children and adults and the role of Lp(a) as a CAD risk factor.

Effects of short-term treatment with insulin-like growth factor-I and growth hormone on serum lipoprotein (a) in growth hormone-deficient adults

“…The findings of our well-controlled, short-term crossover study corroborate and strengthen the long-term data of Laron et al (1) in children with GH insensitivity syndrome. The results provide strong evidence that the decreasing effect of IGF-I cannot be explained by the suppression of GH secretion, and that circulating IGF-I does not mediate the potentially deleterious effects of GH on Lp(a) concentrations, as suggested previously (5).…”

“…In their recent article, Laron et al (1) reported that serum lipoprotein (a) Lp(a) concentrations were increased in response to 6-9 months treatment with growth hormone (GH) in GH-deficient patients and diminished after long-term insulin-like growth factor-I (IGF-I) treatment in children with GH insensitivity (Laron syndrome). They conclude that the two peptide hormones have opposite effects on serum Lp(a).…”

Views From Within and Beyond: Narratives of Cardiac Contractile Dysfunction Under Senescence

“…A dose-dependent relationship between IGF-1 administration and lipoprotein (a) reduction in patients with Laron syndrome was observed (84). Long-term growth hormone treatment increases and IGF-1 decreases circulating levels of lipoprotein (a), which may have clinical relevance in view of the increasing use of human GH in children and adults and the role of lipoprotein (a) as a cardiovascular disease risk factor (85,86).…”

Response to European Journal of Endocrinology 1997 137 459-466 and 450-452: Effect of GH on lipoprotein (A) in GH deficiency

“…These authors do not seem to be aware of other papers published recently on the same topic by both the Swedish group (1) as well as ours (2)(3)(4), wherein the Swedish group treated adult patients with hGH for short periods, and we treated both adult growth hormone deficiency (GHD) patients and children for a period of at least 1 year.…”