Growth hormone in the management of female infertility

Magon, Navneet; Agrawal, Swati; Malik, Sonia; Babu, KM

doi:10.4103/2230-8210.84876

Cited by 9 publications

(12 citation statements)

References 9 publications

(8 reference statements)

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“…Growth hormone has been proposed as a novel therapy for both male and female infertility with promising results in a wide spectrum of conditions and patients groups (Magon, Agrawal, Malik, & Babu, ; Magon, Singh, Saxena, & Sahay, ). Especially in females, GH has been shown to enhance ovarian stimulation in poor responders during IVF/ICSI cycles; Administration of GH increased the number of MII oocytes retrieved and the number of embryos obtained (Yu et al., ).…”

Section: Discussionmentioning

confidence: 99%

Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1

et al. 2018

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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been proposed to play a pivotal role in male infertility due to their anabolic effects. The aim of this study was to investigate possible associations between seminal plasma levels of GH and IGF-1 and sperm parameters. Fifty men participated in this study. Semen analysis was performed, while cell-free seminal plasma was collected following sperm centrifugation. Seminal plasma concentrations of IGF-1 and GH were determined by enzyme-linked immunosorbent assay (ELISA). Due to the presence of asthenozoospermia in all participants who presented with abnormal sperm parameters, the participants were further subdivided into normal (group A), asthenozoospermic (group B) and asthenozoospermic plus at least one additional abnormal parameter (group C). A marginally nonsignificant statistical difference (p = 0.063) was revealed between the GH levels corresponding to the asthenozoospermic and the normal group with the latter presenting with higher GH levels. A statistically significant positive correlation (p < 0.05) was noted between levels of GH and IGF-1 in group C. The above relationship has also been observed in men with low sperm concentration, vitality, volume and abnormal morphology. These novel findings require further investigation in order for the biological significance of those associations to be clarified.

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Section: Discussionmentioning

confidence: 99%

Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1

et al. 2018

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“…growth hormone (gh) is produced by pituitary gland and ovary apart from it being produced from pituitary. growth hormone is used in management of female infertility by playing in ovarian stimulation and increased pregnancy rates in poor responders infertility women 59 .…”

Section: Pituitary Glandmentioning

confidence: 99%

Epidemiology of Female Infertility; A Review of Literature

Direkvand-Moghadam¹,

Delpisheh²,

Khosravi³

2013

Biosci., Biotechnol. Res. Asia

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The prevalence of infertility is varies worldwide ranging from 3% to 7%. The consequences of infertility are societal repercussions, personal suffering, psychological effects, clinical depression and sexual dysfunction. Therefore, the aim of the present study was a systematic review of the literature to determine the main risk factors of female infertility. MEDLINE, EMBASE and Cochrane Database were searched from 1980-2013. Information about study objectives, participants and type of study were searched systematically with extensive key words to optimize the sensitivity of data collection. Eighty-two published articles were included in the overall review. Ovarian factors, tubal and peritoneal factors, anomalies, advanced ages (over 35 years), hormonal disorders, habits, genetic factors, medical conditions and life style are the main causes of infertility in women. Changes of lifestyle, identifying and controlling chronic diseases, rapid and suitable treatments for sexually transmitted diseases can increase the chance of women fertility process.

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“…GH may also have an indirect effect on improving oocyte quality through activating synthesis of insulin-like growth factor (IGF)-I or promoting follicle-stimulating-hormone-induced ovarian steroidogenesis (5, 6). Since GH is involved in the regulation of female and male infertility, it has consequently been applied in the management of infertility for many years (7), especially in patients with poor ovarian response or poor prognosis (8–11). During ovarian stimulation, GH administration can improve the success rate of in vitro fertilization (IVF) (12, 13) probably through the beneficial effects of GH on oocyte quality as indicated by a higher number of mature oocytes and embryos arriving at the transfer stage and a higher fertility rate in GH-treated patients (8, 10, 11, 14).…”

Section: Introductionmentioning

confidence: 99%

Application of Growth Hormone in in vitro Fertilization

Hao

Gao

2019

Front. Endocrinol.

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Growth hormone (GH) is a peptide hormone secreted mainly by the anterior part of the pituitary gland and plays a critical role in cell growth, development, and metabolism throughout the body. GH can not only directly influence human oocytes and cumulus cells but also indirectly improve oocyte quality through activating synthesis of insulin-like growth factor-I or promoting follicle-stimulating hormone-induced ovarian steroidogenesis. Since GH can regulate female and male infertility, it has been applied in the management of infertility for many years, especially in patients with poor ovarian response or poor prognosis. During ovarian stimulation, GH administration might improve the success rate of in vitro fertilization (IVF) probably through the beneficial effects of GH on oocyte quality as indicated by a higher number of mature oocytes and embryos arriving at the transfer stage and a higher fertility rate in GH-treated patients. However, there is still great controversy in the application of GH in IVF. While some researchers showed that pregnancy, implantation and live birth rates could be increased by ovarian pretreatment with GH, others did not support GH as an effective adjuvant for infertility treatment because the live birth rate was not increased. This study reviewed and summarized recent advancements and benefits in clinical application of GH, trying to reach a just unbiased conclusion regarding the effect of GH therapy in IVF.

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Growth hormone in the management of female infertility

Cited by 9 publications

References 9 publications

Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1

Association between male Infertility and seminal plasma levels of growth hormone and insulin-like growth factor-1

Epidemiology of Female Infertility; A Review of Literature

Application of Growth Hormone in in vitro Fertilization

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