Growth hormone (GH) release following thyrotropin-releasing hormone (TRH) injection in manic patients receiving lithium carbonate

Yamaguchi, Naohiko; Tanimoto, Kenji; Kuromaru, Shoshiro

doi:10.1016/0306-4530(80)90029-3

Cited by 13 publications

(2 citation statements)

References 29 publications

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“…Studies in depressed patients on lithium maintenance are consistent with this view (Fyroe et al, 1973;Takahashi et al, 1975;McLarty et al, 1975McLarty et al, , 1978Lindstedt et al, 1977;Cho et al, 1979;Yamaguchi et al, 1980 T4, increased levels of basal TSH, and exaggerated TSH responses to TRH may be observed in varying degrees. linical hypothyroidism may occur in 5 % to 30 % of patlents (Jefferson et al, 1983;Hu/lin, 1978) and there is increasing e\'idence that this is limited to female patients (Fyroe et al, 1973;Cho et al, 1979;Lindstedt et al, 1977).…”

Section: The Effects O[ Antidepressant Drugs On Honnones O[mentioning

confidence: 82%

Hormones of the Hypothalamic-pituitary-thyroid Axis: A Psychoneuroendocrine Perspective

Loosen¹

1986

Pharmacopsychiatry

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Although relationships between hormones of the hypothalamic-pituitary-thyroid (HPT) axis and behavior have been suspected for more than two centuries, there existed no framework within which they could be understood. It now appears that disturbances in the HPT-axis have more to do with affective state than with any other aspect of mentation, save possibly cognition. First, depression is the most frequently observed psychiatric symptom in patients suffering from hypothyroidism. Second, approximately 30% of euthyroid patients with major depression show a blunted, i.e., attenuated TSH response after TRH administration. Third, it is now well established that a small dose of thyroid hormone will accelerate the antidepressant effect of tricyclic antidepressants (TCA) in women, and convert TCA non-responders into responders in both sexes. Fourth, administration of TRH may induce an increased sense of well-being and relaxation in some patients and healthy volunteers. However, little is known about the pathophysiologic mechanism whereby evocative emotional factors express their effect on the HPT axis, or whereby thyroid gland alterations express their behavioral effects. Longitudinal, prospective studies of both patients with thyroid disease and patients with depression (through close collaboration between endocrinology and psychiatry) are most likely to separate cause and effect in most instances.

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Section: The Effects O[ Antidepressant Drugs On Honnones O[mentioning

confidence: 82%

Hormones of the Hypothalamic-pituitary-thyroid Axis: A Psychoneuroendocrine Perspective

Loosen¹

1986

Pharmacopsychiatry

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“…Maeda et al [1975], Takahashi et al [1975], Naeije et al [1978], Schlienger et al [1980], Yamaguchi et al [1980], and Ramseier et al [1980] observed in some of their patients the same abnormal GH release after TRH stimu lation, while Linkowski et al [1980]. Gregoire and Brauman [ 1980] and Kirkegaard et al [1981] did not.…”

mentioning

confidence: 97%

Abnormal Anterior Pituitary Responsiveness to Hypothalamic Hormones in Primary Affective Disorders

Brambilla

Scarone²,

Massironi³

et al. 1982

Neuropsychobiology

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Abnormal anterior pituitary responsiveness to acute administration of thyrotropin-releasing hormone was investigated in 8 patients, 6 women and 2 men, with primary affective disorders in a depressive phase and in 2 women with schizoaffective disorders. Thyrotropin-releasing hormone, 500 µg i.v., induced a rise of plasma growth hormone levels in 1 patient suffering from primary affective disorders and in the 2 schizoaffective subjects, a rise of follicle-stimulating hormone in 1 schizoaffective patient, of luteinizing hormone in the 2 schizoaffective patients, an excessive prolactin rise in 5 patients with primary affective disorders and in 1 schizoaffective subject and a flat response of thyroid-stimulating hormone in 4 patients with primary affective disorders and in 2 schizoaffective patients. Desimipramine was given at a dose of 50–100 mg/day for 3–5 weeks. The thyrotropin-releasing hormone stimulation test was repeated when the patients were improving or after 5 weeks of treatment without improvement. The hormonal impairments tended to disappear in those patients showing symptomatic improvement and were still present in those who did not improve.

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Nonspecific Pituitary Responses to Hypothalamic Hormones in Basic and Clinical Research

Locatelli

Müller

1984

Psychoneuroendocrine Dysfunction

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Growth hormone (GH) release following thyrotropin-releasing hormone (TRH) injection in manic patients receiving lithium carbonate

Cited by 13 publications

References 29 publications

Hormones of the Hypothalamic-pituitary-thyroid Axis: A Psychoneuroendocrine Perspective

Hormones of the Hypothalamic-pituitary-thyroid Axis: A Psychoneuroendocrine Perspective

Abnormal Anterior Pituitary Responsiveness to Hypothalamic Hormones in Primary Affective Disorders

Nonspecific Pituitary Responses to Hypothalamic Hormones in Basic and Clinical Research

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