1990
DOI: 10.1677/joe.0.1240199
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Growth hormone (GH) autofeedback action in the neonatal rat: involvement of GH-releasing hormone and somatostatin

Abstract: It is known that in adult rats, GH by itself and by promoting secretion of the somatomedins acts at the level of the hypothalamus to trigger release of somatostatin and decrease output of GH-releasing hormone (GHRH), thereby inhibiting further secretion of GH. To assess whether these mechanisms are already operative in the early postnatal period, we have evaluated the effect of short-term administration of GH in 10-day-old rats. Twice-daily s.c. administration of 25 micrograms human GH/rat, from days 5 to 9 of… Show more

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Cited by 11 publications
(2 citation statements)
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“…for 5 days induced a 35% decrease of GHRH mRNA in the hypothalamus, decreased pituitary GH content, and abolished the GH rise due to acute admin istration of GHRH. Coadministration of GHRH (20 ng/ 100 g body weight b.i.d., s.c. for 5 days) reestablished the ability of GHRH to elicit GH release in GH-treated pups [29]. The relevance of these findings for the GH therapy of nonclassically GH-deficient short children [30,31] whose GHRH-secreting structures are still preserved [32] does not escape attention (see also below).…”
Section: Growth-hormone-releasing Hormonementioning
confidence: 86%
“…for 5 days induced a 35% decrease of GHRH mRNA in the hypothalamus, decreased pituitary GH content, and abolished the GH rise due to acute admin istration of GHRH. Coadministration of GHRH (20 ng/ 100 g body weight b.i.d., s.c. for 5 days) reestablished the ability of GHRH to elicit GH release in GH-treated pups [29]. The relevance of these findings for the GH therapy of nonclassically GH-deficient short children [30,31] whose GHRH-secreting structures are still preserved [32] does not escape attention (see also below).…”
Section: Growth-hormone-releasing Hormonementioning
confidence: 86%
“…Experimental observations (Cella et al., 1990; MacGregor and Leng, 2005) demonstrate that hypothalamic–serotoninergic activity is directly related to GH secretion in the rat, and that serotoninergic pathways participate in GH negative feed‐back effects in hypothalamus. Therefore a possibility to explain the fall of blood concentrations of GH in TF‐rats, can be found in the fact that serotoninergic neuronal pathways, that seem to play an essential role in control of pituitary hormone secretion (or release?…”
Section: Discussionmentioning
confidence: 99%