Growth hormone (GH) and GH-releasing hormone (GHRH): Co-localization and action in the chicken testis

Martínez-Moreno, Carlos G.; López-Marı́n, Luz M.; Carranza, Martha; Giterman, Daniel; Harvey, S.; Arámburo, Carlos; Luna, Maricela

doi:10.1016/j.ygcen.2014.01.013

Cited by 15 publications

(10 citation statements)

References 44 publications

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“…The results obtained showed that the treatment of Sertoli cells with growth hormone did not have significant effects on the expression of SCF, and it was suggested that the actions of GHRH could be mediated by its receptor present in Sertoli cells and not by the growth hormone (Gallego et al, 2005). These findings are also supported by the study of Martínez-Moreno and colleagues showing that GHRH treatment stimulated the proliferative activity in chicken testes (Martinez-Moreno et al, 2014).…”

Section: Other Hormones Playing a Role In The Regulation Of Scf/c-kitsupporting

confidence: 77%

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Figueira

Cardoso

Correia

et al. 2014

Progress in Histochemistry and Cytochemistry

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Section: Other Hormones Playing a Role In The Regulation Of Scf/c-kitsupporting

confidence: 77%

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Figueira

Cardoso

Correia

et al. 2014

Progress in Histochemistry and Cytochemistry

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“…GHRH receptors have a wide distribution in humans, including Leydig cells, Sertoli cells, germ cells, and the prostate gland, suggesting GHRH may exert testicular actions distinct from GH [ 120 ]. In chickens, GHRH is colocalized with GH in Leydig cells and tubular myocytes and more abundantly in germ-line cells [ 121 ]. GHRH receptors are also present in the chicken testes [ 122 ].…”

Section: Male Fertilitymentioning

confidence: 99%

Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions

Hull

Harvey

2014

International Journal of Endocrinology

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119

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The somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. Axiomatically, since optimal body composition enhances reproductive function, general somatic actions of GH modulate reproductive function. A growing body of evidence supports the hypothesis that GH also modulates reproduction directly, exerting both gonadotropin-dependent and gonadotropin-independent actions in both males and females. Moreover, recent studies indicate GH produced within reproductive tissues differs from pituitary GH in terms of secretion and action. Accordingly, GH is increasingly used as a fertility adjunct in males and females, both humans and nonhumans. This review reconsiders reproductive actions of GH in vertebrates in respect to these new conceptual developments.

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“…It has been described that GHRH is the main stimulatory regulator of pituitary GH expression and secretion [47], and it has also been reported to stimulate GH expression in chicken testis [48] and in quail immortalized neuroretinal (QNR/D) cells [49]. The expression of GHRH-R was previously reported in thymocytes and splenocytes of rats [50,51], fish [52], and in human T-lymphocytes [53].…”

Section: Discussionmentioning

confidence: 94%

Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures

Pech-Pool

Berumen

Martínez-Moreno

et al. 2020

IJMS

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It is known that growth hormone (GH) is expressed in immune cells, where it exerts immunomodulatory effects. However, the mechanisms of expression and release of GH in the immune system remain unclear. We analyzed the effect of growth hormone-releasing hormone (GHRH), thyrotropin-releasing hormone (TRH), ghrelin (GHRL), and somatostatin (SST) upon GH mRNA expression, intracellular and released GH, Ser133-phosphorylation of CREB (pCREBS133), intracellular Ca2+ levels, as well as B-cell activating factor (BAFF) mRNA expression in bursal B-lymphocytes (BBLs) cell cultures since several GH secretagogues, as well as their corresponding receptors (-R), are expressed in B-lymphocytes of several species. The expression of TRH/TRH-R, ghrelin/GHS-R1a, and SST/SST-Rs (Subtypes 1 to 5) was observed in BBLs by RT-PCR and immunocytochemistry (ICC), whereas GHRH/GHRH-R were absent in these cells. We found that TRH treatment significantly increased local GH mRNA expression and CREB phosphorylation. Conversely, SST decreased GH mRNA expression. Additionally, when added together, SST prevented TRH-induced GH mRNA expression, but no changes were observed in pCREBS133 levels. Furthermore, TRH stimulated GH release to the culture media, while SST increased the intracellular content of this hormone. Interestingly, SST inhibited TRH-induced GH release in a dose-dependent manner. The coaddition of TRH and SST decreased the intracellular content of GH. After 10 min. of incubation with either TRH or SST, the intracellular calcium levels significantly decreased, but they were increased at 60 min. However, the combined treatment with both peptides maintained the Ca2+ levels reduced up to 60-min. of incubation. On the other hand, BAFF cytokine mRNA expression was significantly increased by TRH administration. Altogether, our results suggest that TRH and SST are implicated in the regulation of GH expression and release in BBL cultures, which also involve changes in pCREBS133 and intracellular Ca2+ concentration. It is likely that TRH, SST, and GH exert autocrine/paracrine immunomodulatory actions and participate in the maturation of chicken BBLs.

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Growth hormone (GH) and GH-releasing hormone (GHRH): Co-localization and action in the chicken testis

Cited by 15 publications

References 44 publications

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions

Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures

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