Growth hormone (GH) and brain trauma

Devesa, Jesús; Reimunde, Pedro; Devesa, Pablo; Barberá, Matías; Arce, V.

doi:10.1016/j.yhbeh.2012.02.022

Cited by 81 publications

(77 citation statements)

References 95 publications

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“…Apart of its effects on brain repair after an injury [7][8][9][10][11][12], we first reported that GH administration 70 was able to regenerate transected sciatic nerve in rats [13], a finding also reported by other authors 71 [14,15], and still unpublished data from our group indicate that GH and rehabilitation improve the …”

mentioning

confidence: 59%

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Devesa¹,

Alonso²,

López³

et al. 2016

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Caudal regression syndrome (CRS) is a congenital abnormality characterized by an 17incomplete development of the spinal cord (SC) and other abnormalities. We studied a 9-months 18 old CRS child presenting: interruption of SC at L2-L3 level, sacral agenesis, lack of innervation of 21(NSCs), we treated him with GH and rehabilitation, trying to induce the recovery of main sequelae. 22GMFM-88 test score was 12.31%. After a blood analysis, GH treatment (0.3 mg/day, 5 days/week, 3 23 months and then 15 days without GH) and rehabilitation commenced. This protocol was followed 24 during 5 years, being the last GH dose 1 mg/day. Blood analysis and physical exams were performed

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confidence: 59%

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Devesa¹,

Alonso²,

López³

et al. 2016

Preprint

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“…Despite the severity of brain injuries suffered, eight months after his traffic accident, he came back to his University studies and normal life. We published this case 11 years later ( [26] see Case 1).…”

Section: Discussionmentioning

confidence: 97%

“…We used GH, although there was no deficit of the hormone, because of its well-known effects on brain repair after an injury [23][24][25][26][27]. In fact, one of us (JD) was the first (December 2002) in using GH to treat early a young man with a diffuse axonal injury, traumatic SHA and brainstem affectation, whose vital future was unpredictable.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

Quintana¹,

Agra²,

Outeiral³

et al. 2018

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Abstract:To describe the cognitive evolution of a patient who suffered a subarachnoid haemorrhage resulting in a total loss of his cognitive functions. The patient was initially treated with GH (0.8 mg/day), melatonin (50 mg/day) and neurorehabilitation 1 year after his brain damage, during 3 months. Then continued with GH (0.5 mg/day, 6 months/year, during 2 years) and melatonin treatments and neurorehabilitation (3 days/week). 5 years later the patient came back to our Centre due to the absence of recent memory and personal and spatio-temporal orientation and he received an intensive specific neurorehabilitation, including EINA (Auditory Stimulation and Neurosensory Integration), together with GH (0.8 mg/day) and melatonin, for 6 months. At discharge of his first treatment period cognitive functions showed very poor changes but these had been improved when he came back 5 years later. A review carried out 8 years after SHA demonstrated that the patient significantly recovered in all the cognitive functions and he was able to live an independent life. GH plays a key role on cognition, including its actions on recent memory. Melatonin, in turn, helps as a neuroprotective agent. A specific neurostimulation must be performed so that the effects of GH can be expressed. Within neurostimulation, EINA seems to play a very important role for enhancing the effects of medical and rehabilitative treatments on brain plasticity.

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“…A schematic representation of this concept is shown in Figure 1. Therefore, it would be possible that given that our patients receive GH treatment for increasing brain repair [26][27][28][29][30], the hormone might have been the factor responsible for PSH. However, this possibility has to be discarded since in the first case the patient had not been treated with the hormone because of being weekend, and in the second case PSH occurred before the daily administration of GH would have taken place.…”

Section: Discussionmentioning

confidence: 99%

Fever Due to Infection or Muscle Heat?

Devesa

Puell

Castellanos

et al. 2017

MOJAP

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Paroxysmal sympathetic hyperactivity is a frequent condition in patients that suffered a TBI, but also other kinds of brain damage, characterized by a myriad of signs and symptom such as high temperature, tachycardia, tachypnea, hypertension, profuse sweating and spastic extension of legs and arms. The presence of high temperature may lead to suspect about any infective process whose analysis can put at risk the life of the patient, while in fact these symptom appear as a consequence of an increased release of catecholamines occurring because of the disruption of central pathways. Muscle spasticity produces a great heat that contributes to the central origin of hyperthermia. Here we describe two cases that presented PSH after different brain injuries. Both were in coma. One of them after a severe TBI and the other one because of a very important brain infection. PSH in the first case was due to a renal colic and PSH was resolved with propofol. The second case developed PSH suddenly before a session of physiotherapy. The rapid detection of the problem led us to use propranolol and in 40 minutes the patient was in normal conditions. We conclude that the knowledge of PSH and its rapid treatment should be mandatory in hospitals and centers devoted to rehabilitate neurological patients.

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Growth hormone (GH) and brain trauma

Cited by 81 publications

References 95 publications

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

Fever Due to Infection or Muscle Heat?

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