Growth hormone excess and sternohyoid muscle mechanics in rats

Attal, Pierre; Claes, Victor; Bobin, S.; Chanson, P.; Kamenický, Peter; Zizzari, Philippe; Lecarpentier, Yves

doi:10.1183/09031936.00171808

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…Finally, a role of altered neuromuscular control of the pharyngeal muscles cannot currently be ruled out. Indeed, in an animal model of acromegaly (GC rats), we observed myopathy of the sternohyoid muscle, a dilator muscle of the pharynx (122).…”

Section: Acromegaly and Osamentioning

confidence: 96%

Endocrine Aspects of Obstructive Sleep Apnea

Attal

Chanson

2010

The Journal of Clinical Endocrinology &Amp; Metabolism

219

136

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Context: Some endocrine and metabolic disorders are associated with a high frequency of obstructive sleep apnea (OSA), and treatment of the underlying endocrine disorder can improve and occasionally cure OSA. On the other hand, epidemiological and interventional studies suggest that OSA increases the cardiovascular risk, and a link between OSA and glucose metabolism has been suggested, via reduced sleep duration and/or quality.Evidence Acquisition: We reviewed the medical literature for key articles through June 2009.Evidence Synthesis: Some endocrine and metabolic conditions (obesity, acromegaly, hypothyroidism, polycystic ovary disease, etc.) can be associated with OSA. The pathophysiological mechanisms of OSA in these cases are reviewed. In rare instances, OSA may be improved or even cured by treatment of underlying endocrine disorders: this is the case of hypothyroidism and acromegaly, situations in which OSA is mainly related to upper airways narrowing due to reversible thickening of the pharyngeal walls. However, when irreversible skeletal defects and/or obesity are present, OSA may persist despite treatment of endocrine disorders and may thus require complementary therapy. This is also frequently the case in patients with obesity, even after substantial weight reduction. characterized by recurrent episodes of apnea or hypopnea due to total or partial pharyngeal collapse and temporary upper airway (UA) obstruction during sleep, resulting in repeated episodes of hypoxemia and hypercapnia. Frequent arousal ensures pharynx opening and restores airflow, but it fragments sleep and alters its quality. OSA associated with excessive daytime sleepiness is referred to as the OSA syndrome (OSAS). In the United States, 24% of men and 9% of women have OSA, and 4 and 2% of middle-aged men and women, respectively, have OSAS (1, 2). Similar figures have been found in Europe and Asia (3). ConclusionsOSA is pertinent to endocrinologists for at least three reasons. First, some endocrine and metabolic disorders (obesity, acromegaly, hypothyroidism, etc.) are associated with a high frequency of OSA, and treatment of the underlying endocrine disorder can improve and occasionally cure OSA. Second, epidemiological and interventional

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Section: Acromegaly and Osamentioning

confidence: 96%

Endocrine Aspects of Obstructive Sleep Apnea

Attal

Chanson

2010

The Journal of Clinical Endocrinology &Amp; Metabolism

219

136

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“…Myopathy is evident on pathology as muscle fiber degeneration and abnormal collagen are observed 40 , 41 . These findings translate to enhanced muscle fatigue, as demonstrated in a murine model with effects on sternohyodal muscle 42 .…”

Section: Respiratory Complicationsmentioning

confidence: 74%

Updates in rare and not-so-rare complications of acromegaly: focus on respiratory function and quality of life in acromegaly

2020

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Acromegaly is a complex disease with excessive growth hormone and insulin-like growth factor 1 (IGF-1) causing multisystem effects, particularly cardiovascular, respiratory, and metabolic. Psychological concerns and poor quality of life (QoL) are also major disease consequences. This review is intended for clinicians and focuses on the latest developments related to respiratory and QoL effects of long-term growth hormone excess. Along with biochemical disease control, patient treatment satisfaction and outcomes have become major treatment objectives; current knowledge and tools to evaluate and manage this aspect of the disease are described. Sleep apnea syndrome and other derangements of lung function and apparatus, from pathophysiology to treatment, and evaluation tools and determinants of QoL in patients with acromegaly are discussed.

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“…The mechanisms leading to the high prevalence of OSA in patients with acromegaly are summarised in Fig. 7 (231,234,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254).…”

Section: Osa and Acromegalymentioning

confidence: 99%

MECHANISMS OF ENDOCRINOLOGY: Mechanisms of disease: the endocrinology of obstructive sleep apnoea

Lavrentaki

Ali

Cooper

et al. 2019

European Journal of Endocrinology

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Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious comorbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. This bidirectional relationship between OSA and the endocrine system has been increasingly recognised in experimental and epidemiological studies and there are an increasing number of studies examining the effects of OSA treatment on endocrine conditions and vice versa. In this review article, we will critically appraise and describe the impact of OSA on the endocrine system including obesity, dysglycaemia, the pituitary, the thyroid, the adrenals, the reproductive system and the bones. In each section, we will assess whether a bidirectional relationship exists, and we will describe the potential underlying mechanisms. We have focused more on recent studies and randomised controlled trials where available and attempted to provide the information within clinical context and relevance.

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Growth hormone excess and sternohyoid muscle mechanics in rats

Cited by 9 publications

References 48 publications

Endocrine Aspects of Obstructive Sleep Apnea

Endocrine Aspects of Obstructive Sleep Apnea

Updates in rare and not-so-rare complications of acromegaly: focus on respiratory function and quality of life in acromegaly

MECHANISMS OF ENDOCRINOLOGY: Mechanisms of disease: the endocrinology of obstructive sleep apnoea

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