Growth hormone deficiency in patients with histiocytosis X

Dean, Heather; Bishop, Agnes J.; Winter, Jeremy S.D.

doi:10.1016/s0022-3476(86)80223-2

Cited by 31 publications

(15 citation statements)

References 7 publications

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“…A single study has previously reported normal growth despite GH deficiency (GHD) in pediatric LCH without obesity [5]. Similar observations exist in children with obesity and hypopituitarism due to craniopharyngioma where elevated serum insulin was hypothesized to mediate growth in the presence of GHD.…”

Section: Discussionmentioning

confidence: 66%

Primary Hypothyroidism, Precocious Puberty and Hypothalamic Obesity in Langerhans Cell Histiocytosis

et al. 2010

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A 5 year old girl presented with central diabetes insipidus and primary hypothyroidism. No clinical or radiological evidence of Langerhans cell histiocytosis (LCH) was present. Absent posterior pituitary bright spot was seen in magnetic resonance imaging of the brain. She subsequently developed severe headache, massive obesity, accelerated growth and thelarche. A repeat MRI of the brain revealed hypothalamic tumor. Hormonal investigations revealed, paradoxically, undetectable growth hormone on a clonidine stimulation test. Langerhans cell histiocytosis was proved on electron microscopy of the thyroid tissue. There needs to be a high degree of suspicion for LCH as an etiology of primary hypothyroidism, especially in the presence of diabetes insipidus. Precocious puberty, accelerated growth despite growth hormone deficiency, hypothalamic obesity may occur in pediatric LCH. CNS lesions may have an evolving course, thus repeat neuroimaging is important.

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Section: Discussionmentioning

confidence: 66%

Primary Hypothyroidism, Precocious Puberty and Hypothalamic Obesity in Langerhans Cell Histiocytosis

et al. 2010

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“…GHD is usually diagnosed years after posterior pituitary deficiency and is responsible for growth retardation. Described initially as a rare complication [72,73], GHD is now estimated to affect up to 42% of LCH patients with DI [74]. Its frequency increases with time, underlining the need for long-term follow-up.…”

Section: Endocrine Disordersmentioning

confidence: 99%

Langerhans cell histiocytosis

Blesa

Candel

Vercet³

et al. 2008

Clin Transl Oncol

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Langerhans cell histiocytosis (LCH) is a poorly understood proliferative disease, with different patterns of clinical presentation. Currently it is classified according to the number and type of system involved and the degree of organ dysfunction. The aetiology of the disease remains uncertain, and in some cases the disease is polyclonal, suggesting a reactive condition. Many cytokines have been implicated in the pathogenesis of LCH. Different therapeutic approaches can be considered depending on the affected organ, including surgery, radiotherapy and chemotherapy. Long-term organ dysfunction may remain, despite disease control and/or eradication, making indefinite supportive treatment mandatory. Here we present a literature review on all of the aspects of the disease, treatment approaches and existing protocols, and finally an adult clinical case.

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“…Such patients may have diabetes insipidus and growth and sexual developmental abnormalities (BRAUNSTEIN and KOHLER 1981). The most common endocrinopathy is diabetes insipidus, which occurs in approximately 300/0--40% of children with multisystem disease (DEAN et al 1986;DUNGER et al 1989;McLELLAND et al 1990). However, pathologic changes in the pituitary or hypothalamus are not necessarily evident in patients with diabetes insipidus who die of their disease (GRAMATOVICI and D' ANGlO 1988).…”

Section: Multiple Lesionsmentioning

confidence: 99%

“…Patients with proptosis may also be at higher risk for diabetes insipidus. Although patients with LCH and diabetes insipidus may have abnormal growth hormone responses to exercise, arginine, hypoglycemia, or Ldopa/propranolol, the incidence of children exhibiting growth retardation to the extent that growth hormone therapy is required appears to be quite low (DEAN et al 1986). Magnetic resonance imaging (MRI) with gadolinium enhancement provides excellent images by revealing a thickened pituitary stalk, a thickened infundibulum, or a thickened median eminence of the hypothalamus without the bright posterior pituitary signal seen in normals (ARICO et al 1991).…”

Section: Multiple Lesionsmentioning

confidence: 99%

Radiation Therapy in Pediatric Oncology

Cassady¹

1994

Medical Radiology

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The use of general descriptive names, registered, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Thomson Press (India) Ltd., New Delhi SPIN: 1 0042321 21 13130/SPS -5 4 3 2 I 0 -printed on acid-free paper PrefaceThis book provides a thorough review of the role that radiation therapy currently plays in the management of most childhood tumors. Extensively augmented with figures and tables where appropriate, it also provides a concise review of current diagnostic and therapeutic approaches for major childhood malignancies. Extensive and up-to-date reference lists are an added benefit. Chapters on principles of pediatric radiation therapy, etiology of childhood tumors, and newer, molecular approaches in pediatric oncology are provided.Authors include leaders in the field writing on their particular areas of interest and expertise, providing a diversity of approach useful to the reader.Many people have been responsible for this book. Primary thanks must go to our many childhood patients and their parents who have allowed us the privilege of treating them. Appreciation and thanks are due to my many teachers and particular role models, HENRY

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Growth hormone deficiency in patients with histiocytosis X

Cited by 31 publications

References 7 publications

Primary Hypothyroidism, Precocious Puberty and Hypothalamic Obesity in Langerhans Cell Histiocytosis

Primary Hypothyroidism, Precocious Puberty and Hypothalamic Obesity in Langerhans Cell Histiocytosis

Langerhans cell histiocytosis

Radiation Therapy in Pediatric Oncology

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