Growth hormone deficiency in cleft lip and palate patients

Abstract

Citation: Abdollahi-Fakhim Sh, Bayazian Gh, Shiva S, Sohrabpour M, Ebrahimzade Y. Growth hormone deficiency in cleft lip and palate patients.

Assessment of sella turcica area and skeletal maturation patterns of children with unilateral cleft lip and palate

“…The researchers linked these findings with the concurrent embryological development of foetal oral cavity and hypophysis. They also emphasized the importance of malnutrition in this particular group of patients . In contrast; Van der Plas et al reported normal hypophysis volume on MRI despite shorter stature and slower growth rate in females with CLP.…”

“…Although some studies and clinical observations report that the skeletal development of CLP patients is deficient to some extent when compared to normal individuals, some researchers suggest that these individuals have accelerated skeletal development . Some early studies attributed developmental deficiency to various factors such as malnutrition or genetics, but it has been alternatively suggested that dysfunction of the hypophysis and endocrinological system may also affect skeletal growth of children with orofacial clefts …”

“…Many recent studies have drawn attention to the relationship between CLP and developmental problems. Although its pathophysiology is still not definitively known, hereditary factors and malnutrition related to CLP are implicated as possible causes . Alternatively, functional disorders or structural anomalies of the hypophysis are shown to be one of the factors causing developmental deficiency in individuals with isolated unilateral cleft lip and palate (UCLP) .…”

“…There are studies examining the correlation between CLP and development by assessing height increase and body mass index; however, there are few studies on skeletal maturation stage. Although the correlations between hypophysis function/size and body mass index or sella turcica dimensions in individuals with CLP have been studied independently, there is no published article evaluating skeletal maturity and sella turcica dimensions collectively …”

Estudio Comparativo de Crecimiento Estaturo Ponderal y Acceso a Lactancia Materna Durante el Primer Año de Vida de Niños con Fisura Labio Máxilo Palatina versus Niños sin Fisura

“…En el caso particular del género masculino, estos presentaron diferencias significativas en el promedio de longitud durante casi toda la trayectoria desde el nacimiento hasta el primer año de vida; esto pudo ocurrir por la presencia de niños con talla alta o en el límite de ésta en los niños del grupo control, aumentando considerablemente el promedio de longitud de niños sin FLMP. Además, se ha reportado en la literatura una asociación entre la deficiencia de hormona de crecimiento y la presencia de FLMP, afectando en la estatura de estos niños/as, sin embargo esto debe estudiarse en cada individuo luego de descartar factores nutricionales que estén afectando en el crecimiento (Abdollahi-Fakhim et al, 2015 ).…”