Growth Hormone Binding Proteins in Plasma – An Update

In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels

“…In addition, whereas growth is primarily stimulated by the pulsatile component of GH secretion, hepatic GH receptor numbers and plasma GHBP levels are closely related to basal levels of GH secretion [10]. GH receptor numbers are also influenced by nutrient intake [15] and in uraemic rats, low GH receptor expression was primarily caused by reduced food intake [16]. Reduced liver GH binding in fasting may partly explain the nutritional changes in circulating IGF-I levels [17], although dietary protein restriction alone does not markedly affect GH binding, and in this situation reduced levels of IGF-I appear to be the result of post-re-1549 Fig.…”

A novel bioassay for human somatogenic activity in serum samples supports the clinical reliability of immunoassays

“…It has been shown that from 5 to 50% of GH present in the circulation is bound to GHBP, the shed extracellular portion of the GHR (Baumann, 1990), and this is apparent in Fig. 8.…”

Differential effects of octreotide treatment and transsphenoidal surgery on growth hormone—binding protein levels in patients with acromegaly

“…In healthy adults GHBP levels tend to correlate with IGF-I concentrations. 3 Before treatment, GHBP levels did not correlate with any other measured element of the GH-IGF-I axis. Successful transsphenoidal surgery tended to restore a positive correlation between GHBP and IGF-I, although this did not reach statistical significance, perhaps because of the small sample size.…”