Growth hormone and prolactin secretion in the carcinoid syndrome

Feldman, Jerome M.; Plonk, James W.; Bivens, Carl H.; Lebovitz, Harold E.; Handwerger, Stuart

doi:10.1097/00000441-197505000-00007

Cited by 34 publications

(6 citation statements)

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“…Our results confirm previous observations that patients with the carcinoid syndrome may have elevated GH levels which are not suppressed by glucose loading (Feldman et al, 1975). It has been postulated that increased serotonin levels in these patients are responsible for the GH hypersecretion.…”

Section: Discussionsupporting

confidence: 91%

Effect of Somatostatin on Abnormal Growth Hormone and Prolactin Secretion in Patients With the Carcinoid Syndrome

Gómez-Pan

Scanlon

Thorner

et al. 1979

Clinical Endocrinology

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Growth hormone (GH) secretion has been studied in two patients with the carcinoid syndrome during glucose loading and growth hormone-release inhibiting hormone (GHRIH, somatostatin) infusion. Both patients had elevated fasting GH levels which were not suppressed by glucose; GH levels fell rapidly during GHRIH infusion. One patient also had hyperprolactinaemia with galactorrhoea and the prolactin (PRL) levels were unaltered by GHRIH. The association between carcinoid tumours and abnormalities of GH and PRL secretion is discussed.

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Section: Discussionsupporting

confidence: 91%

Effect of Somatostatin on Abnormal Growth Hormone and Prolactin Secretion in Patients With the Carcinoid Syndrome

Gómez-Pan

Scanlon

Thorner

et al. 1979

Clinical Endocrinology

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“…In the great majority of surgically treated patients, pituitary adenomata have been found, suggesting that a primary neoplastic process of the somatotrophs was the cause of the acromegaly. However, recent reports linking carcinoid tumors and pancreatic islet cell tumors with acromegaly confirm that hypersomatotropinemia can sometimes be a secondary phenomenon (1)(2)(3)(4)(5)(6)(7)(8)(9). This report describes a patient with acromegaly and amenorrheagalactorrhea with striking pituitary enlargement which resolved clinically, biochemically, and radiologically after resection of a large jejunal carcinoid with diverse and unusual secretory capabilities.…”

mentioning

confidence: 72%

“…In several of the carcinoid-acromegaly syndrome reports, serum PRL was elevated as well (2,7). However, this is the first report of a clearly documented resolution of the amenorrhea-galactorrhea syndrome after resection of a carcinoid tumor.…”

Section: Discussionmentioning

confidence: 99%

Resolution of Acromegaly, Amenorrhea-Galactorrhea Syndrome, and Hypergastrinemia after Resection of Jejunal Carcinoid

Spero¹,

White²

1985

The Journal of Clinical Endocrinology & Metabolism

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A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia. In addition, she had hypergastrinemia with abnormal secretory dynamics and evidence of a large pituitary tumor with suprasellar extension and erosion of the floor of the sella turcica. Evaluation of secretory diarrhea revealed a large abdominal tumor, which on removal was found to be a carcinoid of the jejunum. Postoperatively, the acromegaly, amenorrhea-galactorrhea, and hypergastrinemia resolved, and the pituitary returned to normal size, with regrowth of the sella floor. The carcinoid tumor was shown by immunoperoxidase staining to contain GH-releasing hormone.

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“…In rats 5-hydroxytryptamine when injected intraventricularly in the brain causes GH release (Collu et al, 1972). In humans Feldman et al (1975) studied GH secretion in patients with metastatic carcinoid tumours and the carcinoid syndrome. Fortyfive per cent of their patients had elevated GH levels that did not suppress after an intravenous glucose load although none of the patients were clinically acromegalic.…”

Section: Discussionmentioning

confidence: 99%

Acromegaly Due to Production of a Growth Hormone Releasing Factor by a Bronchial Carcinoid Tumour

Shalet

Beardwell

MacFarlane

et al. 1979

Clinical Endocrinology

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We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperosidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary monolayer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a production.

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Growth hormone and prolactin secretion in the carcinoid syndrome

Cited by 34 publications

References 0 publications

Effect of Somatostatin on Abnormal Growth Hormone and Prolactin Secretion in Patients With the Carcinoid Syndrome

Effect of Somatostatin on Abnormal Growth Hormone and Prolactin Secretion in Patients With the Carcinoid Syndrome

Resolution of Acromegaly, Amenorrhea-Galactorrhea Syndrome, and Hypergastrinemia after Resection of Jejunal Carcinoid

Acromegaly Due to Production of a Growth Hormone Releasing Factor by a Bronchial Carcinoid Tumour

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