Growth hormone and prolactin regulate human neural stem cell regenerative activity

Pathipati, Praneeti; Gorba, Thorsten; Scheepens, Arjan; Goffin, Vincent; Sun, Yirui; Fraser, Mhoyra

doi:10.1016/j.neuroscience.2011.05.029

Cited by 78 publications

(54 citation statements)

References 159 publications

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“…1,2 The PRL-induced regulation of the nervous system is manifested in such important and relevant processes as maternal behavior, energy balance, food intake, stress and trauma responses, anxiety, neurogenesis, migraine and pain. [3][4][5][6][7][8][9][10][11][12][13][14] To understand this wide spectrum of processes that potentially influences the etiology of a vast array of disease conditions affecting millions of people, it is essential to delineate the specific mechanisms responsible for the PRL control of function in various neuronal circuitries. The aim of the present review is to summarize the current knowledge and recent progress made in understanding mechanisms responsible for PRL-induced regulation of neuronal functions and the channels involved.…”

Section: Introductionmentioning

confidence: 99%

Prolactin receptor in regulation of neuronal excitability and channels

2014

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Section: Introductionmentioning

confidence: 99%

Prolactin receptor in regulation of neuronal excitability and channels

2014

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“…Stem cell proliferation declines with age and this may contribute to cognitive impairment in the elderly 33 . The presence of GH receptors in neural stem cells suggests the ability of GH to regulate their activities 34 . Blackmore and his colleagues showed that a seven-day intracerebroventricular infusion of GH increases neural stem cell numbers and augments neurogenesis activity in vitro 35 .…”

Section: Discussionmentioning

confidence: 99%

Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

Malek

Sarkaki

Zahediasl

et al. 2017

Arq. Neuro-Psiquiatr.

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REVIEW Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged ratsEfeito da injeção intrahipocampal de hormônio do crescimento humano recombinante sobre a plasticidade sináptica em ratos envelhecidos lesados do núcleo basalis magnocellularis Many common age-related problems are due to neuroendocrine phenomena including memory impairment and Alzheimer's disease (AD) 1 . Alzheimer's disease is a senile neurodegenerative disorder with specific pathological changes in the brain that can cause progressive dementia 2 and is characterized by serious memory problems 3 . The causes and mechanisms of AD are still under intensive investigation 4 . According to the cholinergic hypothesis, high destruction of basal forebrain cholinergic neurons, particularly the nucleus basalis magnocellularis (NBM), have been seen in ABSTRACTIn this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rats and intrahippocampal injection of growth hormone vehicle (L + Veh); NBM-lesioned and intrahippocampal injection of growth hormone (10, 20 and 40 µg.2 µl-1) (L + GH). In vivo electrophysiological recording techniques were used to characterize maintenance of long-term potentiation at distinct times (1, 2, 3, 24 and 48 hours) after high-frequency stimulation. The population spike was enhanced significantly for about 48 hours following tetanic stimulation in rats treated with a dose-dependent growth hormone compared to the vehicle group (p < 0.05), possibly through neuronal plasticity and neurogenesis in affected areas.Keywords: growth hormone; hippocampus; basal nucleus of Meynert; long-term potentiation; Alzheimer disease; cognition disorders. RESUMONeste estudo, propusemos que a administração de hormônio hipocampal do crescimento em animais envelhecidos com deficiência de hormônio do crescimento pode compensar a potencialização em longo prazo e a plasticidade sináptica em ratos lesados do núcleo basalis magnocellularis (NBM). Ratos machos Wistar foram divididos aleatoriamente em seis grupos (sete ratos em cada grupo) de ratos falso-operados saudáveis (Cont); ratos lesados do NBM (L); ratos lesados do NBM e injeção intrahipocampal de veículo de hormônio do crescimento (L + Veh); ratos lesados do NBM e injeção de hormônio do crescimento (10, 20 e 40 μg.2 μl-1) (L + GH). Técnicas de registro eletrofisiológico in vivo foram utilizadas para caracterizar a manutenção da potencialização em longo prazo em momentos distintos (1, 2, 3, 24 e 48 horas) após estimulação de alta frequência. O pico populacional aumentou significativamente cerca de 48 horas após a estimulação tetânica em ratos tratados com um hormônio do crescimento...

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“…Moreover, in that study we also demonstrated that exogenous GH cooperates with the hormone produced in the neural progenitors to increase their proliferation in response to a brain damage. The effects of GH treatment on the proliferation of neural stem cells, had been also observed in adult mice and rats [47,48] and human foetal hippocampus [49]. Moreover, a functional MRI study demonstrated that GH treatment improved learning and the working memory in GH-deficient GHD) children [40,42].…”

Section: Discussionmentioning

confidence: 84%

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

Quintana¹,

Agra²,

Outeiral³

et al. 2018

Reports

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Abstract:To describe the cognitive evolution of a patient who suffered a subarachnoid haemorrhage resulting in a total loss of his cognitive functions. The patient was initially treated with GH (0.8 mg/day), melatonin (50 mg/day) and neurorehabilitation 1 year after his brain damage, during 3 months. Then continued with GH (0.5 mg/day, 6 months/year, during 2 years) and melatonin treatments and neurorehabilitation (3 days/week). 5 years later the patient came back to our Centre due to the absence of recent memory and personal and spatio-temporal orientation and he received an intensive specific neurorehabilitation, including EINA (Auditory Stimulation and Neurosensory Integration), together with GH (0.8 mg/day) and melatonin, for 6 months. At discharge of his first treatment period cognitive functions showed very poor changes but these had been improved when he came back 5 years later. A review carried out 8 years after SHA demonstrated that the patient significantly recovered in all the cognitive functions and he was able to live an independent life. GH plays a key role on cognition, including its actions on recent memory. Melatonin, in turn, helps as a neuroprotective agent. A specific neurostimulation must be performed so that the effects of GH can be expressed. Within neurostimulation, EINA seems to play a very important role for enhancing the effects of medical and rehabilitative treatments on brain plasticity.

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Growth hormone and prolactin regulate human neural stem cell regenerative activity

Cited by 78 publications

References 159 publications

Prolactin receptor in regulation of neuronal excitability and channels

Prolactin receptor in regulation of neuronal excitability and channels

Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation

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