Growth hormone and insulin-like growth factor-I accelerate PMSG-induced differentiation of granulosa cells

Hutchinson, Laura; Findlay, Jock K.; Herington, Adrian C.

doi:10.1016/0303-7207(88)90091-3

Cited by 69 publications

(27 citation statements)

References 34 publications

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“…The increasing FSH concentration during the last 30 days of pregnancy shown in the present study were similar to those described previously. The only consistent feature of previous studies of FSH concentration occurred during the last days of pregnancy when there appeared to be an increase, beginning 30 days prior to parturition [3,7,14]. This rise in ir-IGF-I and FSH levels and the timing of the first ovulation 10-14 days later corresponds to what is seen at mid-diestrus in the mare, leading to a wave of follicular growth and ovulation 10-14 days later [10,13].…”

Section: Discussionsupporting

confidence: 80%

“…derar40@hotmail.com s i g n i f i c a n t l y h i g h e r t h a n t h e p o s t -p a r t u m concentration, with the IGF-I level in late gestation decreasing gradually until the day of parturition [4]. IGF-I may play an important role in maintaining lutealgranulosa cell function in the absence of a constant FSH stimulus [7]. The main objective of the present study was to characterize the plasma profile of IGF-I during the period immediately preceding foaling in mares and that following it.…”

mentioning

confidence: 99%

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Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed: its Pattern, Physiological Function and Relation to Other Hormones

Derar

Haramaki²,

Hoque

et al. 2006

JES

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Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 99%

Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed: its Pattern, Physiological Function and Relation to Other Hormones

Derar

Haramaki²,

Hoque

et al. 2006

JES

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“…Additionally, numerous in vitro experiments have pointed to the importance of growth hormone in ovarian physiology. Thus, GH enhances folliclestimulating hormone-induced differentiation of cultured granulosa cells [7,8]. Perfusion of ovaries with GH results in increased follicular growth, in stimulation of oocyte maturation, and in enhancement of estradiol synthesis [9].…”

Section: Introductionmentioning

confidence: 97%

Growth Hormone-Related Effects on Apoptosis, Mitosis, and Expression of Connexin 43 in Bovine In Vitro Maturation Cumulus-Oocyte Complexes1

Kölle

Stojković

Boie

et al. 2003

Biology of Reproduction

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Pituitary LH and FSH are known to be the major regulators of ovarian function. In the last few years, however, there has been evidence that growth hormone (GH) is also involved in ovarian regulation. Therefore, the aim of our study was to elucidate the mechanisms of GH action during in vitro maturation (IVM) of bovine cumulus-oocyte complexes (COCs). As shown by detection of the nuclear cell proliferation-associated antigen Ki-67, COCs matured in vitro in the presence of GH revealed a significantly (P < 0.05) higher proportion of proliferating cumulus cells (12.6%) compared with the COCs matured in the control medium TCM 199 (9.9%). In contrast, the percentage of proliferating cells was not increased by supplementation of the medium with a combination of GH and insulin-like-growth factor I (IGF-I). Apoptosis as determined by TUNEL (terminal doxynucleotidyl transferase mediated dUTP nick-end labeling) was significantly (P < 0.05) reduced in the cumulus cells by GH treatment. COCs matured with a combination of GH and IGF-I revealed the lowest percentage of apoptotic cells (11%). The localization and quantification of the gap junction protein connexin 43 (Cx 43) demonstrated that GH induced a significant decrease in the synthesis of the Cx 43 protein in the cumulus cells. Our results imply that GH increases cumulus expansion by promotion of cell proliferation and inhibition of apoptosis. Whereas the increase in cell proliferation is a direct effect of GH, the antiapoptotic effects of GH during in vitro maturation are modulated by IGF-I. Stimulatory effects of GH on oocyte maturation are correlated with changes in the synthesis of gap junction proteins.

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“…This effect was mainly exerted by an amplification of gonadotropin actions (Jia et al 1986;Hsu and Hammond 1987;Hutchinson et al 1988). In some of these studies the GH effects were mimicked by IGF-I, involved enhanced LH receptor induction, or had a possible influence on cAMP synthesis.…”

Section: Evidence For Direct Gonadal Site Of Action For Ghmentioning

confidence: 99%

Growth hormone (GH) and reproduction: a review

Gac

Blaise

Fostier

et al. 1993

Fish Physiol Biochem

171

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ResumeLes interactions entre les fonctions de croissance et de reproduction mises en evidence chez de nombreux vert6br6s, sont particulierement aigiies A certaines tapes du cycle vital des poissons. Nous d6crivons les interactions endocrines existant entre les axes somatrope et gonadotrope en insistant sur le role jou6 par l'hormone de croissance (GH). L'analyse compare de ces phenomenes chez les mammiferes, les poissons et les amphibiens permet de sugg6rer que la GH joue un rle sp6cifique dans la physiologie de la puberty, la gametog6nese et la fertility. Nous mettons en evidence l'apport original des tudes effectu6es sur le module poisson dans ce champ d'investigation. AbstractInteraction between growth and reproduction occurs in many vertebrates and is particularly obvious at certain stages of the life cycle in fish. Endocrine interactions between the gonadotropic axis and the somatotropic axis are described, the potential role of GH being emphasised. A comparative analysis of these phenomena in mammals, amphibians and fish, suggests a specific role of GH in the physiology of puberty, gametogenesis and fertility. It also shows the original contribution made by studies on the fish model in this field of investigations.

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Growth hormone and insulin-like growth factor-I accelerate PMSG-induced differentiation of granulosa cells

Cited by 69 publications

References 34 publications

Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed: its Pattern, Physiological Function and Relation to Other Hormones

Immunoreactive Insulin-Like Growth Factor in Plasma during Pre- and Post-Partum Periods of Thoroughbred Mares from which the Newborn were Removed: its Pattern, Physiological Function and Relation to Other Hormones

Growth Hormone-Related Effects on Apoptosis, Mitosis, and Expression of Connexin 43 in Bovine In Vitro Maturation Cumulus-Oocyte Complexes1

Growth hormone (GH) and reproduction: a review

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