Growth Failure in Children with Metabolic Alkalosis and with Metabolic Acidosis

Should Blood Gas Analysis Be Part of the Diagnostic Workup of Short Children? Auxological Data and Blood Gas Analysis in Children with Renal Tubular Acidosis

“…In contrast, Glaser et al [16] suggested a role for growth hormone in maintaining normal acid-base homeostasis, and thus growth hormone deficiency should be considered in cases of acidosis and growth failure. Based on literature from the 1970s, Tsuru and Chan [17] suggested that growth failure in acidosis is probably related to disturbances in vitamin D and calcium metabo-lism. This was not in accordance with later studies as summarized by Donckerwolcke et al [4] who also discussed the inconsistent findings on either impaired or normal growth hormone secretion during acidosis.…”