Abstract:Growth factor (GF) receptors are extracellular receptors which, when bound by growth factors, initiate intracellular signaling for promoting cellular proliferation, survival,
and differentiation. The amount of signaling is generally controlled by both the levels of growth factor and the levels of GF receptors present in the cell, particularly at the cell surface. This review will focus on the mechanisms of endocytosis and postendocytic trafficking that serve to control the levels of GF receptors. The classical… Show more
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