“…The pathway genes that are highly expressed in Lgr5+ progenitors include Kcnh8 , Mknk1 , Shc1 , Cdon , Disp2 , Erbb4 , Hhip , Ihh , Npc1 , Dll1 , Dll3 , Dll4 , Figf , Hes5 , Mfng , Neurl1a , Notch4 , Rbpjl , Dkk1 , Fgf4 , Wnt4 , Wnt8b , Fat3 , Rassf2 , Tjp2 , Tshz2 , and Tshz3 . Among them, Axin2 (Jan et al, 2013; Jansson et al, 2015), Egf (Lou et al, 2015), Wnt4 (Alvarado et al, 2011), Tjp2 (Kim et al, 2014), Dll1 (Kiernan et al, 2005; Chrysostomou et al, 2012), and Dll3 (Hartman et al, 2007) have already been reported in the inner ear. Some of the pathway genes that are highly expressed in Lgr5- SCs include Akt1 , Atf1 , Bcl2 , Ccnd1 , Dusp6 , Egr1 , Fos , Grb2 , Jun , Kras , Lta , Pik3r1 , Pik3r2 , Plat , Ppp2ca , Rhoa , Dhh , Fgf9 , Fkbp8 , Kctd11 , Prkacb , Ptch1 , Stk3 , Fos , Hesl , Heyl , Krt1 , Ncstn , Psen1 , Ccnd2, Dkk3, Fzd8, Fzd9, Fkbp8, Jun, Nkd1, Rhou , Wif1 , Frzb , Wnt5a, Wnt6 , Ajuba , Amotl2 , Csnk1d , Hipk2 , Mob1a , Pard6g , Stk3 , Wisp1 , Taz , Tead1 , and Wwc1 .…”