Growth factors and pathogenesis

Islam, Soriful; Greco, Stefania; Janjusevic, Milijana; Ciavattini, Andrea; Giannubilo, Stefano Raffaele; D'Adderio, Assunta; Biagini, Alessandra; Fiorini, Rosamaria; Castellucci, Mario; Ciarmela, Pasquapina

doi:10.1016/j.bpobgyn.2015.08.018

Cited by 34 publications

(35 citation statements)

References 97 publications

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“…The incidence of uterine fibroids increases with age [ 4 ]. At present, although there are a lot of research about the prevention and treatment of uterine fibroids [ 5 , 6 , 7 ], the etiopatogenesis of uterine fibroids is still unclear [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries

et al. 2017

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ObjectiveTo estimate the association between uterine fibroids and adverse obstetric outcomes.MethodsThis was a retrospective cross-sectional study of 112,403 deliveries from 14 provinces and 39 different hospitals in 2011 in mainland China. We compared pregnancy outcomes in women with and without uterine fibroids who underwent detailed second trimester obstetric ultrasonography during 18 to 22 weeks. Obstetric outcomes include cesarean delivery, breech presentation, preterm delivery, placenta previa, placental abruption, premature rupture of membranes and neonatal birthweight. Univariate analyses and multivariate logistic regression analyses were performed.ResultsOf 112,403 women who underwent routine obstetric survey, 3,012 (2.68%) women were identified with at least 1 fibroid. By univariate and multivariate analyses, the presence of uterine fibroids was significantly associated with cesarean delivery (Adjusted odds radio [AOR] 1.8, 95% confidence interval [CI] 1.7–2.0), breech presentation (AOR 1.3, 95% CI 1.2–1.5) and postpartum hemorrhage (AOR 1.2, 95% CI 1.1–1.4). The size of uterine fibroids and location in uterus had important effect on the mode of delivery. The rates of PPH were significantly higher with increasing size of the uterine fibroid (P<0.001). And the location of fibroid (intramural, submucosal or subserosal) also have a statistically significant impact on the risk of PPH (5.6% [subserosal] vs 4.7% [submucosal] vs 8.6% [intramural]).ConclusionPregnant women with uterine fibroids are at increased risk for cesarean delivery, breech presentation and postpartum hemorrhage. And different characteristics of uterine fibroids affect obstetric outcomes through different ways. Such detailed information may be useful in risk-stratifying pregnant women with fibroids.

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Section: Introductionmentioning

confidence: 99%

Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries

et al. 2017

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“…Выявлено, что в секреторную фазу менструального цикла под воздействием прогестерона повышается пролиферация в лейомиоцитах, а активность апоптоза снижается, что способствует активному росту миоматозных узлов [6]. Исследования патогенеза и морфогенеза миомы матки показали, что для миоматозных узлов характерны нарушение процессов пролиферации и апоптоза лейомиоцитов, а также дисбаланс между ингибиторами и активаторами ангиогенеза [9][10][11][12].…”

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The molecular mechanisms and morphological manifestations of leiomyoma reduction induced by selective progesterone receptor modulators

2017

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The molecular mechanisms of tumor reduction involved the reduced Ki-67 expression and elevated p16, lower VEGF and TGF-β, diminished SRC-1 expression with the maintained level of PR, ER, and NCoR-1. Overall, this is suggestive of enhanced apoptosis and reduced leiomyoma proliferation and angiogenesis induced by SPRM and indicative of the expediency of using ulipristal acetate as a preoperative agent for organ-sparing surgery in reproductive-aged patients with uterine myoma, menorrhagias, and anemia.

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“…A number of differentially expressed growth factors (EGF, HB-EGF, PDGF, IGF, TGF-a, TGF-b, VEGF, aFGF, bFGF, activin-A, and myostatin) have been identified in leiomyoma and myometrium (15)(16)(17)(18). These growth factors can activate multiple signaling pathways (Smad 2/3, ERK 1/2, and PI3K) (19)(20)(21)(22) and regulate major cellular processes, including proliferation and fibrosis, which are linked to uterine leiomyoma development and growth.…”

mentioning

confidence: 99%

Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells

Janjusevic

Greco

Islam

et al. 2016

Fertility and Sterility

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Growth factors and pathogenesis

Cited by 34 publications

References 97 publications

Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries

Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries

The molecular mechanisms and morphological manifestations of leiomyoma reduction induced by selective progesterone receptor modulators

Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells

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