Growth Factors and Cytokines in Uterine Leiomyomas

Andersen, Jessica L.

doi:10.1055/s-2007-1016336

Cited by 91 publications

(52 citation statements)

References 101 publications

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“…The precise aetiology of fibroids is still unknown, but it is clear that oestrogen and progesterone can cause growth 1,2 . They are common in women of child-bearing age and have an overall incidence of 40-60% by 35 years of age 3 .…”

Section: Introductionmentioning

confidence: 99%

The impact of fibroid characteristics on pregnancy outcome

Lam

Best

Kumar

2014

American Journal of Obstetrics and Gynecology

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Objective: To assess the influence of different characteristics of fibroids on pregnancy outcome.Study design: We identified women with fibroids ≥4 cm in size on ultrasonography at the dating scan between January 2002 and December 2012. The size (4-7cm, 7-10cm, >10cm), number (multiple/single), location (lower uterus/body of uterus) and type (intramural, combination of intramural/subserosal, subserosal) were ascertained. Medical records were reviewed to obtain pregnancy outcomes (preterm delivery, birth weight, mode of delivery, estimated blood loss, postpartum haemorrhage and admission for fibroid related pain).Results: 121 patients with 179 pregnancies were identified. Preterm delivery was more likely in those with multiple fibroids compared to single fibroids (18% v 6% p=0.05). The location of fibroid had an important effect on mode of delivery with a higher caesarean section rate for fibroids in the lower part of uterus than in the body of the uterus (86% v 40% p=0.01), a higher rate of postpartum haemorrhage (22% v 11%p=0.03) and greater estimated blood loss This information can be used to aid counselling women antenatally and in risk stratifying patients.

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Section: Introductionmentioning

confidence: 99%

The impact of fibroid characteristics on pregnancy outcome

Lam

Best

Kumar

2014

American Journal of Obstetrics and Gynecology

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“…1,2 It is estimated that 20 -30% of women over the age of 30 will develop a leiomyoma. 1,3 Approximately half of the cases exhibit cytogenetic abnormalities.…”

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confidence: 99%

Expression of N‐terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas

Moon

Zeng

Premdas

et al. 2002

Intl Journal of Cancer

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Genetic analyses and mRNA expression studies have implicated CUTL1 as a candidate tumor-suppressor gene in uterine leiomyomas and breast cancers. However, modulation of CDP/Cux, the protein encoded by CUTL1, does not agree with this notion. The activity of CDP/Cux, which is the DNA binding subunit of HiNF-D, was upregulated as normal cells progressed into S phase and constitutively elevated in several tumor cell lines. Activation of CDP/Cux at the G 1 /S transition involved the proteolytic processing of the protein to generate a shorter isoform. Uterine leiomyomas represent a unique reagent for molecular analysis because they are resected as homogenous tumor tissue together with the adjacent normal myometrium and they are often very large. In the present study, proteins were isolated from 16 pairs of matched tumors and adjacent myometrium and analyzed by Western blot and electrophoretic mobility shift assays. Strikingly, in 11/16 tumors, the steady-state level of small CDP/ Cux isoforms was increased compared to normal control tissue. Where tested, a corresponding increase in CDP/Cux stable DNA binding activity was observed. DNA sequencing analysis of CUTL1 cDNAs from 6 leiomyomas, including 4 with LOH of CUTL1, did not reveal any gross rearrangement or point mutations. Altogether these findings suggest that CUTL1 is probably not the tumor suppressor on 7q22. Moreover, the frequent increase in smaller CDP/Cux isoforms indicates that molecular events associated with the truncation of CDP/Cux proteins may be selected in uterine leiomyomas.

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“…1,2 The cause of the fibroids is unknown, but however, it is estimated to be caused by estrogens and progestrones which proliferate tumor growth. 3,4 Fibroids are seen to rarely occur before menarche and reduce after menopause. The may be single or multiple and have a negative impact on the reproductive system, and are capable of causing severe morbidity among the women with deterioration of quality of life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of fibroids: a study in a semiurban area in Telangana, India

Srilatha

Verabelly

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Uterine fibroids, also known as Leiomyoma, are the most common benign neoplasm in the female genital tract and originate from the myometrium´s smooth muscle. Although the uterine fibroids are diagnosed frequently, the prevalence of it in the local populations is unknown. Therefore, this study was done to observe the prevalence of the fibroids in our geographic area. Methods: 4487 women aged between 18-50 years who came to our gynec OPD out of which 522 were positive for the presence of fibroids, were included into the study. Ultrasound examination was done for all the patients. During this examination, the uterine dimensions and the structure were assessed. The number of the fibroids were counted and noted. Biopsy sample was taken from the fibroids and sent to pathology lab for further histological examination. Results: Out of the 4487 patients included into the study, 11.6% had fibroids. The predominant age group which was positive the presence of fiberoids was 40-59 years. 59.8% of them were married while 40.2% were either unmarried or divorced or widowed. The body mass index for most of them was within the normal range (60.3%), while some were slightly overweight. The most common cause of the patients to seek medical advice was menstrual disorder (37.7%) which included heavy, irregular or no periods. Conclusions: Fibroids was significantly associated with age, married marital status, overweight, pregnancy, menopause, childbirth and the presence of menorrhagia. Early detection would help in early management and thereby reduce the morbidity.

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Growth Factors and Cytokines in Uterine Leiomyomas

Cited by 91 publications

References 101 publications

The impact of fibroid characteristics on pregnancy outcome

The impact of fibroid characteristics on pregnancy outcome

Expression of N‐terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas

Prevalence of fibroids: a study in a semiurban area in Telangana, India

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