“…Moreover, the majority of the publications concern the entrapment of heat labile peptides and proteins. These proteins and peptides have been entrapped into VPGs and liposomes for different routes of administration: oral [21,30,31], nasal [33], and iv injection [17,20,28,29], or as VPG-depot formulations [13,34,48]. Various organs were targeted as therapeutic sites: cancerous tissue [10,26,35], the central nervous system (CNS) and brain [28,32,33], liver [31], and skin [18,19].…”