Growth factor regulation of uncoupling protein-1 mRNA  expression in brown adipocytes

García, Bibian; Obregón, Marı́a Jesús

doi:10.1152/ajpcell.01396.2000

Cited by 25 publications

(12 citation statements)

References 37 publications

(25 reference statements)

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“…Further studies are needed to identify changes in deiodinase activity or plasma thyroidstimulating hormone (TSH) levels after the switch to WD. The UCP1 expression in BAT was significantly increased after 72 h on WD, which is in line with increased body temperature after 72 h. T 3 is known to increase UCP1 expression in vitro (17) and to increase BAT UCP1 expression to normal levels in hypothyroid fetus (34). In this study, the increased T 3 levels in the WD mice may explain the increased UCP1 expression.…”

Section: Discussionsupporting

confidence: 76%

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Bjursell¹,

Gerdin²,

Lelliott³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

118

103

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The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. WD for only 24 h resulted in a marked physiological shift in energy homeostasis, including increased body weight gain, body fat, and energy expenditure (EE) but an acutely lowered locomotor activity. The acute reduction in locomotor activity was observed after only 3–5 h on WD. The energy intake and energy absorption were increased during the first 24 h, lower after 72 h, and normalized between 7 and 14 days on WD compared with mice given chow diet. Core body temperature and EE was increased between 48 and 72 h but normalized after 21 days on WD. These changes paralleled plasma T3 levels and uncoupling protein-1 expression in brown adipose tissue. After 21 days of WD, energy intake and absorption, EE, and body temperature were normalized. In contrast, the locomotor activity was reduced and body weight gain was increased over the entire 21-day study period on WD. Calculations based on the correlation between locomotor activity and EE in 2-h intervals at days 21–23 indicated that a large portion of the higher body weight gain in the WD group could be attributed to the reduced locomotor activity. In summary, an acute and persisting decrease in locomotor activity is most important for the effect of WD on body weight gain and obesity in mice.

show abstract

Section: Discussionsupporting

confidence: 76%

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Bjursell¹,

Gerdin²,

Lelliott³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

118

103

View full text Add to dashboard Cite

show abstract

“…Changes in mRNA and protein levels of Agt and Angptl4 were consistent. Among these, Agt and Egf may promote differentiation of preadipocytes 35, 36 and Angptl4 may inhibit fat deposition by depressing LPL activity 37 . Figure 8 showed that Agt directly inhibits the expression of Lep, Hmgcr, and Ldlr and Egf negatively regulates the expression of Lep.…”

Section: Discussionmentioning

confidence: 99%

High-salt intake negatively regulates fat deposition in mouse

Cui

Yang

Zheng

et al. 2017

Sci Rep

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High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, fat mass, the percentage of abdominal fat, heat production, rate of oxygen consumption and the respiratory exchange ratio of mice on a HS diet were significantly decreased (P < 0.01 or 0.05) compared with mice on a normal-salt (NS) diet. An in vitro experiment with differentiating pre-adipocytes showed reduced fat deposition in the presence of high concentrations of NaCl (>0.05 M). Abdominal fat mRNA profiles and protein measurements showed that 5 known genes involved in lipolysis were up-regulated significantly and 9 genes related to lipogenesis were down-regulated in HS mice. Abundant genes and some proteins (ATP2a1, AGT, and ANGPTL4) related to calcium ion metabolism or the renin-angiotensin system (RAS) were differentially expressed between HS and NS mice. Of special interest, CREB1 phosphorylation (S133 and S142), a key factor involved in calcium signaling and other pathways, was up-regulated in HS mice. By IPA analysis, a network mediated by calcium was established providing the molecular mechanisms underlying the negative effect of HS on fat deposition.

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“…In addition to the endogenous expression of markers of BAT activity, we found using antibody arrays that circulating FGF1 was regulated in a similar way to Ucp1 and Pgc1a in BAT, being induced by HFD and further potentiated by DAG and AZP531 treatment in HFD‐fed mice. FGF1 is increased by food intake and increases sympathetic efferent outflow, as well as having a direct effect on brown adipocyte UCP1 content (55).…”

Section: Discussionmentioning

confidence: 99%

Des‐acyl ghrelin analogs prevent high‐fat‐diet‐induced dysregulation of glucose homeostasis

et al. 2013

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There is clinical evidence that des-acyl ghrelin (DAG) favorably modulates glucose and lipid metabolism, although its mode of action is unknown. A murine model of prediabetes was used to assess possible mechanisms of action for DAG and a newly developed bioactive analog, AZP531. C57BL/6J mice were infused with saline, DAG, or AZP531 continuously for 4 wk, and fed either normal diet (ND) or normal diet for 2 wk followed by a high-fat diet (HFD) for 2 wk. Compared with mice in the ND group, HFD increased body and fat mass, caused glucose intolerance and insulin resistance, had proinflammatory effects in white adipose tissue, and caused lipid accumulation in brown adipose tissue. DAG and AZP531 treatment prevented HFD-induced proinflammatory effects, stimulated expression of mitochondrial function markers in brown adipose tissue, and prevented development of a prediabetic metabolic state. AZP531 also prevented a HFD-induced increase in acyl ghrelin levels. Our data indicate DAG analogs as potential treatment for the prevention of metabolic syndrome.

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Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes

Abstract: García, Bibian, and Maria-Jesú s Obregó n. Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes.

Cited by 25 publications

References 37 publications

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

High-salt intake negatively regulates fat deposition in mouse

Des‐acyl ghrelin analogs prevent high‐fat‐diet‐induced dysregulation of glucose homeostasis

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