2005
DOI: 10.1016/j.ydbio.2005.01.020
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Growth factor regulation of lens development

Abstract: Lens arises from ectoderm situated next to the optic vesicles. By thickening and invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell fate and behavior. Current evidence indicates that FGFs and BMPs are required to induce lens differentiation from ectoderm. In the lens vesicle, posterior cells elongate to form the primary fibers whereas anterior cells differentiate into epithelial cells. The divergent fates of these embryonic cells give the lens its distinctive polarity.… Show more

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Cited by 301 publications
(326 citation statements)
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“…These Dkks display suggestive expression patterns in eye primordia, including pigmented epithelium, choroid and retina (Monaghan et al, 1999). Wnt/b-catenin signaling plays an important role in various stages of eye formation, including early patterning (Esteve and Bovolenta, 2006), retinal development (Van Raay and Vetter, 2004), lens formation (Lovicu and McAvoy, 2005) and eye angiogenesis (Niehrs, 2004a). In humans, loss of LRP5 function causes congenital blindness (pseudoglioma) (Gong et al, 2001).…”
Section: Dkk1 and 2 In Bone Formationmentioning
confidence: 99%
“…These Dkks display suggestive expression patterns in eye primordia, including pigmented epithelium, choroid and retina (Monaghan et al, 1999). Wnt/b-catenin signaling plays an important role in various stages of eye formation, including early patterning (Esteve and Bovolenta, 2006), retinal development (Van Raay and Vetter, 2004), lens formation (Lovicu and McAvoy, 2005) and eye angiogenesis (Niehrs, 2004a). In humans, loss of LRP5 function causes congenital blindness (pseudoglioma) (Gong et al, 2001).…”
Section: Dkk1 and 2 In Bone Formationmentioning
confidence: 99%
“…3B,C). At E12.5, strong staining was observed in both the posterior wall, containing elongating primary fibers and epithelial cells at the anterior pole, which remain undifferentiated and retain their proliferation capacity (McAvoy et al, 1999;Menko, 2002;Lovicu and McAvoy, 2005).…”
Section: Spatial Segregation Of Gad Forms During Lens Developmentmentioning
confidence: 99%
“…Thereafter, mitotically active cells near the equatorial region (termed germinative epithelium) divide and migrate toward the equator, where they elongate and differentiate into secondary lens fiber cells, a process continuing throughout life (McAvoy, 1978;Lovicu and McAvoy, 2005). From E14.5 on, GAD67 expression was localized in both primary and secondary fiber cells, with the strongest labeling at E16.5-E17.5 (Fig.…”
Section: Spatial Segregation Of Gad Forms During Lens Developmentmentioning
confidence: 99%
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“…Its development is directed by means of inductive interactions from specific tissues derived from all embryonic germ layers. Although several genes involved in eye development have been characterized to date, there are still many gaps in our understanding of the molecular pathways involved in this process (reviewed in Fini et al, 1997;Perron et al, 1998;Chow and Lang, 2001;Hanson, 2001;Graw and Loster, 2003;Zuber et al, 2003;Lovicu and McAvoy, 2005).…”
Section: Introductionmentioning
confidence: 99%