Growth Factor-Loaded Nano-niosomal Gel Formulation and Characterization

Moghassemi, Saeid; Hakamivala, Amirhossein; Omidfar, Kobra

doi:10.1208/s12249-016-0579-y

Cited by 36 publications

(35 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This investigation additionally showed a cost-effective method for BSA quantification in niosomes and similar vesicles (8). Secondly, similar span 60 and cholesterol niosomes were loaded with basic fibroblast growth factor, incorporated in agarose hydrogel as a scaffold, and evaluated for their in vitro cell proliferation performance (9). The said delivery system was successful in controlling drug release and improving cell proliferation even in comparison with the niosomal suspension.…”

mentioning

confidence: 90%

See 1 more Smart Citation

Formulation and Delivery of Macromolecules

Morales

2016

AAPS PharmSciTech

View full text Add to dashboard Cite

The field of macromolecule drug development (also known in the literature as biologics, biomacromolecules, and biotechnology drugs) has sharply grown over the past 15 years (1). With a steady growth in total sales, sales per drug type (i.e., therapeutic proteins and peptides, monoclonal antibodies, or vaccines), and innovation, macromolecule drug development continues to make a strong case in contrast with small-molecule drugs (2,3). While most marketed products and clinical trials on macromolecule drugs are injectable dosage forms, there is a drive for more convenient dosage forms evidenced in the body of scientific literature, numerous clinical trials, and a handful of successful products for alternative routes of administration.While extravascular administration has been widely investigated and has shown potential, there are many difficulties associated with absorption of therapeutic macromolecules into the body. For example, oral delivery of macromolecules for intestinal absorption faces a number of well-known limitations including instability in gastric pH, proteolytic enzyme content in the upper gastrointestinal (GI) tract, and insufficient permeation and bioavailability; therefore, encapsulation, targeted release, and novel permeation enhancers have been a focus area of research (4). With the difficulties of GI tract absorption, alternative routes of delivery have also been investigated, including buccal/sublingual, transdermal, and nasal/pulmonary. This special theme of AAPS PharmSciTech explores specific aspects in the state of the art in macromolecule delivery and showcases innovative research strategies intended to improve absorption and performance of dosage forms containing macromolecular drugs.In our review in this Themed Edition, Montenegro-Nicolini and Morales describe the major advancements in mucoadhesive films as dosage forms for buccal administration of macromolecule drugs (5). The review presents the stratified mucosal epithelium as an absorption barrier and introduces strategies to enhance macromolecule permeation. The authors identify solvent casting as the conventional choice for film development; however, recent advancements in hot melt extrusion (6) and inkjet printing (7) could provide new avenues for buccal film product development.Hot melt extrusion of solid dosage forms for macromolecule drug development has been avoided in the past due to potential drug degradation due to the high temperatures and shear achieved during the process. Nonetheless, efforts in using low-glass transition temperature polymers and optimized processing conditions have shown promise. In their article, Cossé et al. focus on systematically investigating all relevant extrusion variables as well as using a lowtemperature processing polymer (6). After suitable formulation development, the authors showed that the extruded implants were able to sustain bovine serum albumin (BSA) release for weeks while maintaining very limited conformation changes in the BSA structure.In an alternative approach for macromolecule dr...

show abstract

mentioning

confidence: 90%

“…In an alternative approach for macromolecule drug formulation in nanostructured systems, two articles detail the development and characterization of niosomes as delivery systems (8,9). Firstly, a formulation optimization study was conducted and BSA release properties of niosomes determined.…”

mentioning

confidence: 99%

Formulation and Delivery of Macromolecules

Morales

2016

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…The design of biomaterials enables to encapsulate biomolecules effectively, release them significantly, and enhance scaffolds regenerative capacity . With this regard, some strategies have focused on the appropriate design and development of biomaterial scaffolds that are incorporated with biomolecules to regulate their release profiles and modulate optimal cell behavior …”

Section: Introductionmentioning

confidence: 99%

“…2,3 With this regard, some strategies have focused on the appropriate design and development of biomaterial scaffolds that are incorporated with biomolecules to regulate their release profiles and modulate optimal cell behavior. [4][5][6] Electrospun nanofibers are regarded as a promising ECMmimicking platform and the effective delivery system of biomolecules which can provide physical support for cellular growth to modulate tissue regeneration. [7][8][9][10][11] Incorporating biomolecules into scaffold interiors can be obtained by directly mixing the biomolecules in a polymer solution during the electrospinning process (as named blend electrospinning) and provides bioactive scaffolds with an initial burst release followed by a sustained release.…”

Section: Introductionmentioning

confidence: 99%

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Ghasemkhah

Latifi

Hadjizadeh

et al. 2019

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

The biomaterials design as core–shell structures opens a new door to the release of susceptible biomolecules in a controllable manner and enables to place natural biomaterials as shell layers to impart the effective biofunctional features at surfaces. In this study, core–shell designed scaffolds were prepared using coaxial electrospinning with hybrid of gelatin (GT)/polycaprolactone (PCL) at different weight ratios as their shell and protein solution as their core, followed by cross‐linking to impart controllable release rates, tunable mechanical properties, and enhanced cytocompatibility. SEM, FM, and TEM confirmed the successful production of uniform core–shell nanofibers and homogeneous protein distribution. Results showed that an increase in GT proportion in the shell resulted in a decrease in fiber diameter, an increase of Young's modulus, and an intense burst release of BSA 0.2% which could be controlled through cross‐linking. The mechanical tests revealed that the GT/PCL combining and cross‐linking improved mechanical properties which correlated with an increase in spreading and proliferation of HUVECs. A slight burst release was also detected from BSA 0.05% and EGF encapsulated GT73P‐cross‐linked scaffold which demonstrated their applicability for a controlled release of dilute proteins. We were able to successfully incorporate two types of protein with different concentrations without supporting polymer into the GT shell to provide scaffolds possessing tunable mechanical properties and controllable release rates through blending with PCL at different ratios and/or cross‐linking. These findings are promising to promote delivery systems of angiogenic growth factors that are needed a sustained release with different rates at each angiogenesis stage. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

show abstract

“…Other uses of niosomes include the treatment of glaucoma using dorzolamide niosomes [121], specific niosomal drug-delivery systems that target the liver [122] and induction of angiogenesis using growth factor-loaded nano-niosomal gel formulations [123]. Moghassemi et al [124] formulated bovine serum albumin-loaded niosomes that have potential use in pharmaceutical and cosmetic applications.…”

Section: Other Applicationsmentioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

View full text Add to dashboard Cite

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

show abstract

Growth Factor-Loaded Nano-niosomal Gel Formulation and Characterization

Cited by 36 publications

References 24 publications

Formulation and Delivery of Macromolecules

Formulation and Delivery of Macromolecules

Potential core–shell designed scaffolds with a gelatin‐based shell in achieving controllable release rates of proteins for tissue engineering approaches

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Contact Info

Product

Resources

About