“…Various growth factors [25,45] and products of growth-related genes, including transforming growth factor-β (TGF-β; [11,47]), fibroblast growth factor (FGF; [47]), thyroxin [4], catecholamines [34,57], angiotensin-2 [3,14,55], c-fos [14,31], and c-myc [52,59], as well as adrenergic stimulation [8,49], are recognized as modulators of embryonic heart development and/or cardiac hypertrophy. However, most of these factors are generally known to be also actively involved in regulating the growth of many other tissues [18].…”