Growth, Enzymes and Hormonal Changes in Offspring of Alcohol‐Fed Rats

Guerri, Consuelo; Esquifino, A.; Sanchis, Rosa; Grisolı́a, Santiago

doi:10.1002/9780470720868.ch6

Cited by 19 publications

(1 citation statement)

References 33 publications

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“…The chronic exposure to ethanol during the lactation period, induces significant metabolic disturbances in mothers, that include alterations in mammary gland function leading to decreased total milk production, and of milk having an increased lipid content (Vilaró et al, 1987). Its continuous ingestion during this phase, alters milk chemical composition Viñas et al, 1987) resulting in the appearance of ethanol and acetaldehyde (Sanchis & Guerri) and exacerbating ethanol effects on the newborn (Guerri et al, 1984). Do Carmo et al (1999) observed that maternal alcohol ingestion decreases milk production, leading to serious malnutrition in the rat offspring, partly compensated by the increased lipid content of milk that leads to metabolic adaptations preventing severe hypoglycemia and maintenance of minimal levels of hepatic glycogen.…”

Section: Introductionmentioning

confidence: 99%

Histometric Study of Alveolar Bone in Rats Submitted to Ethanol During Lactation

Curi

Azoubel

Lopes³

et al. 2008

Int. J. Morphol.

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The present work studied the adverse effects of maternal exposure of rats to alcohol during lactation, on the development of their offspring. Histometric evaluation by karyometry and of the alveolar bone at the level of the first upper molar of the sucking was perfomed. Two groups of animals, one coming from mothers exposed to drinking water containing 20% ethanol during the total lactation period and the other of controls coming from mothers receiving only alcohol-free drinking water during this period. On the 21 first day of lactation the young of each group were aleatorily selected and following anesthesia, their heads severed; after histological treatment, serial 6 µ m sections on the frontal plane at the molar level, stained with hematoxilin and eosin, were obtained. The experimental results produced, suggest that sucking from ethanol-treated mothers, show retarded post-natal growth, their alveolar bones presenting scarce, little calcified trabeculae, and a more abundant bone marrow compared to controls.

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Section: Introductionmentioning

confidence: 99%

Histometric Study of Alveolar Bone in Rats Submitted to Ethanol During Lactation

Curi

Azoubel

Lopes³

et al. 2008

Int. J. Morphol.

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Growth of Rat Embryos in the Serum of Alcohol Drinkers

Beck

Huxham

Gulamhusein

1984

Ciba Foundation Symposium 105 ‐ Mechanisms of Alcohol Damage in Utero

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Prenatal exposure to ethanol alters plasma membrane glycoproteins of astrocytes during development in primary culture as revealed by concanavalin a binding and 5′‐nucleotidase activity

Renau‐Piqueras

Guerri²,

Burgal³

et al. 1992

Glia

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We have investigated the effect of prenatal exposure to ethanol on the extent of binding and surface distribution of the lectin concanavalin A (con A) on rat cortical astrocytes during the periods of proliferation and differentiation in primary culture. The enzymatic activity of the plasma membrane glycoprotein 5'-nucleotidase was also assessed. The cells were obtained from control fetuses (no exposure to ethanol) and from fetuses prenatally exposed to ethanol. The main findings were: 1) both proliferating and differentiating control astrocytes showed two distinct types of surface con A receptors that could correspond to high- and low-affinity binding sites; 2) the extent of con A binding was greater in mature than in proliferating control cells; 3) the distribution of con A on cell surface components changed with differentiation; 4) the activity of 5'-nucleotidase showed a substantial increment during the period of differentiation; and 5) prenatal exposure to ethanol clearly decreased the ability of astrocytes to bind con A, altered the surface distribution of the receptors for this lectin, and decreased the activity of 5'-nucleotidase. These effects were more marked in proliferating cells. In conclusion, it is shown that the extent of con A labeling and the activity of 5'-nucleotidase in astrocytes are dependent on the stage of cell differentiation and that prenatal exposure to ethanol alters the plasma membrane structure of these cells during development.

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Growth, Enzymes and Hormonal Changes in Offspring of Alcohol‐Fed Rats

Cited by 19 publications

References 33 publications

Histometric Study of Alveolar Bone in Rats Submitted to Ethanol During Lactation

Histometric Study of Alveolar Bone in Rats Submitted to Ethanol During Lactation

Growth of Rat Embryos in the Serum of Alcohol Drinkers

Prenatal exposure to ethanol alters plasma membrane glycoproteins of astrocytes during development in primary culture as revealed by concanavalin a binding and 5′‐nucleotidase activity

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