Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes

Register, Hannah M; Yi, Joe; Jensen, Elizabeth T.; Joseph, Robert M.; Kuban, Karl; Frazier, Jean A.; Washburn, Lisa K.; Belfort, Mandy B.; South, Andrew M.; Santos, Hudson P.; Shenberger, Jeffrey S.; Perrin, Eliana M.; Thompson, Amanda L.; Singh, Rachana; Rollins, Julie V.; Gogcu, Semsa; Sanderson, Keia; Wood, Charles T.; Fry, Rebecca C.

doi:10.1016/j.jpeds.2022.08.015

Cited by 5 publications

(5 citation statements)

References 69 publications

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“…One study found poor fetal growth in utero was associated with increased risk for attention-deficit hyperactivity disorder ( 29 ). Another recent study in extremely preterm infants did not find differences with different growth trajectories during NICU hospitalization and behavioral/psychiatric outcomes ( 16 ). Our study also found modest (< 1 point) differences in M-CHAT-R scores during NICU hospitalization.…”

Section: Discussionmentioning

confidence: 95%

“…Another large cohort study found weight velocity following discharge decreased the odds of neurodevelopmental impairment in a non-linear fashion ( 25 ). A study examining growth from discharge to two years found gains in weight/length z-score was associated with decreased odds of cognitive impairment at 10 years old ( 16 ). These studies suggest that growth following NICU discharge should be closely monitored by the pediatrician.…”

Section: Discussionmentioning

confidence: 99%

“…To address this concern, many groups now consider changes in weight or length z-score as a better measure for adequate growth ( 2 , 11 - 13 ). Studies of the relationship between changes in z-score during the initial hospitalization of ELBWs and neurodevelopmental outcomes show mixed results ( 8 , 14 , 15 ), and there has been minimal research evaluating the association of z-score changes after discharge with neurodevelopment ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Strobel

Wood

Valentine

et al. 2023

Preprint

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Introduction: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. Methods In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were examined between birth and hospital discharge, and from discharge to 2 years. The 2-year evaluation included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist (CBCL). Results Among 629 infants, accelerated linear growth from birth to discharge was associated with higher BSID-III cognitive scores (+ 3.2 points [IQR 0.02, 6.4]) while in-hospital GF was not associated with any outcomes. Infants with weight GF after discharge had lower BSID-III motor scores (-3.1 points [-5.9, -0.2]). Infants with accelerated weight growth after discharge had increased odds of behavioral problems on the CBCL (aOR 1.9 [1.03, 3.5]). Discussion In-hospital and post-hospitalization growth metrics are modestly associated with neurodevelopmental outcomes with length gains apparently most beneficial.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Strobel

Wood

Valentine

et al. 2023

Preprint

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“…Also, increased weight velocity following discharge decreased the odds of neurodevelopmental impairment in a non-linear fashion [ 30 ]. Furthermore, a study examining growth from discharge to 2 years found gains in weight/length z-score was associated with decreased odds of cognitive impairment at 10 years old [ 18 ]. These studies suggest that growth following NICU discharge should be closely monitored by the pediatrician and the optimal growth trajectory requires further refinement.…”

Section: Discussionmentioning

confidence: 99%

“…To address this concern, many groups now consider changes in weight, length, or OFC z-score as a better measure for adequate growth [2,[12][13][14][15][16][17]. Studies of the relationship between changes in z-score during the initial hospitalization of ELBWs and neurodevelopmental outcomes show mixed results [8,16,17], and there has been minimal research evaluating the association of z-score changes after discharge with neurodevelopment [18].…”

Section: Introductionmentioning

confidence: 99%

Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

Strobel,

Wood,

Valentine

et al. 2024

J Perinatol

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Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown. Methods This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist. Results Among 590 infants, adjusted in-hospital growth was not associated with any BSID-III subscale. Occipitofrontal circumference (OFC) growth failure (GF) in-hospital was associated with increased adjusted odds of attention problems (aOR 1.65 [1.03, 2.65]), aggressive behavior (aOR 2.34 [1.12, 4.89]), and attention-deficit-hyperactivity symptoms (aOR 1.86 [1.05, 3.30]). Infants with OFC GF at 2 years had lower adjusted BSID-III language scores (−4.0 [−8.0, −0.1]), increased odds of attention problems (aOR 2.29 [1.11, 4.74]), aggressive behavior (aOR 3.09 [1.00, 9.56]), and externalizing problems (aOR 3.01 [1.07, 8.45]) compared to normal OFC growth cohort. Conclusion Infants with OFC GF are at risk for neurodevelopmental and behavioral impairment. Clinical trial registration This study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273.

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Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm

Emmanuel,

Oran,

Jensen

et al. 2024

Pediatr Res

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Growth During Infancy After Extremely Preterm Birth: Associations with Later Neurodevelopmental and Health Outcomes

Cited by 5 publications

References 69 publications

Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm

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