Growth disturbance of frontal lobe in BCECTS presenting with frontal dysfunction

Kanemura, Hideaki; Aihara, Masao

doi:10.1016/j.braindev.2008.12.007

Cited by 24 publications

(29 citation statements)

References 9 publications

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“…Moreover, she presented with a progressive behavioral deterioration simultaneously. Volumetric analysis of the brain may predict function in corresponding regions [6] . Our results show enhanced vulnerability of the prefrontal cortex during the early clinical phase of CSWS.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal Lobe Growth in a Patient with Continuous Spike-Waves during Slow Sleep

Kanemura

Sugita²,

Aihara³

2009

Neuropediatrics

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Epilepsy with continuous spike-waves during slow sleep (CSWS) is characterized by impairment of neuropsychological abilities, frequently associated with behavioral d isorders. These manifestations strongly correlate with frontal lobe dysfunctions. In the present case, an 11-year-old girl presented with progressive behavioral deteriorations after the appearance of electrical status epilepticus in sleep. The duration of CSWS period was 5 months. Serial measurements (at the appearance of the EEG pattern, and 6 months and 1, 2, 3 and 4 years thereafter) of frontal and prefrontal lobe volumes by 3-dimensional magnetic resonance imaging-based volumetry showed growth disturbance of prefrontal lobe volume, particularly prefrontal-to-frontal lobe volume ratio, after the appearance of the EEG pattern when compared with two frontal lobe epilepsy subjects without neuropsychological disorders and 13 control subjects. However, the ratio was restored to the growth ratio and seen to reach control levels, after improvement of the clinical manifestations of CSWS. These results suggest that children with CSWS may be prone to frontal lobe dysfunctions, and that the duration of CSWS period seems to be a significant prognostic factor. The urgent suppression of this EEG abnormality may be necessary to prevent the progression of neuropsychological impairments.

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Section: Discussionmentioning

confidence: 99%

Prefrontal Lobe Growth in a Patient with Continuous Spike-Waves during Slow Sleep

Kanemura

Sugita²,

Aihara³

2009

Neuropediatrics

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“…Abnormalities in functional as well as structural connectivity have been found in other types of childhood epilepsy [11]. Moreover, investigations of conventional MRI scans have revealed structural abnormalities in RE [12], including white matter hyper-intensities [13]. Also, patterns of subtle cortical thickness abnormalities have been described [14].…”

Section: Introductionmentioning

confidence: 99%

Reduced Structural Connectivity between Sensorimotor and Language Areas in Rolandic Epilepsy

et al. 2013

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IntroductionRolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing.MethodsTwenty-three children with RE and 23 matched controls (age: 8–14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm2, 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance.ResultsSeveral reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43).ConclusionIn RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca’s area) and the supramarginal gyrus (Wernicke’s area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.

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“…In other studies Kanemura et al 50 compared the growth of the frontal and prefrontal brain volume in children with benign childhood epilepsy with centro-temporal spikes (BCECTS) with cognitive and behavioral disorders with children with BCECTS without behavioral disorders. They showed that there was a volumetric difference between these two groups, and concluded that the BCECTS with presence of behavioral disorders had a greater volume change of the frontal lobe.…”

Section: Epilepsy and Adhd: Possible Common Physiopathogenic Mechanismsmentioning

confidence: 99%

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

Koneski

Casella

2010

Arq. Neuro-Psiquiatr.

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The association between attention deficit and hyperactivity disorder (ADHD) and epilepsy can cause significant impact on the social life of affected individuals and their families. Clinical studies suggest that 30-40% of people with epilepsy also have ADHD. There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures. Some studies attempt to relate drug interactions between methylphenidate and antiepileptic drugs, but adverse effects of methylphenidate have not been shown clearly. This review presents some neurobiological and physiopathogenic aspects, common to ADHD and epilepsy, from recent research studies, related to pharmacology, neuroimaging and electroencephalography. Possible risk of occurrence of seizures associated with the use of methylphenidate are also discussed. Key words: ADHD, epilepsy, methylphenidate, comorbidities, seizures, antiepileptic drugs.Transtorno de déficit de atenção e hiperatividade em pessoas com epilepsia: diagnóstico e implicações para o tratamento RESUMO A associação entre transtorno de déficit de atenção / hiperatividade (TDAH) e epilepsia pode causar importante impacto na vida social dos indivíduos afetados e seus familiares. Estudos clínicos sugerem que 30-40% das pessoas com epilepsia também apresentam TDAH. Não existem publicações que evidenciem que o tratamento a curto ou longo prazo com metilfenidato aumente o risco de ocorrência de crises epilépticas, e alguns estudos procuram relacionar as interações medicamentosas entre o metilfenidato e as drogas antiepilépticas, porém não foram demonstrados os possíveis efeitos do metilfenidato de uma maneira clara. Apresenta-se a seguir, revisão sobre os aspectos neurobiológicos e fisiopatogênicos comuns ao TDAH e epilepsia, a partir de pesquisas recentes relacionadas a estudos de farmacologia, neuroimagem e eletroencefalografia, e discuti-se os possíveis riscos da ocorrência de crises epilépticas associadas ao uso de metilfenidato.

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Growth disturbance of frontal lobe in BCECTS presenting with frontal dysfunction

Cited by 24 publications

References 9 publications

Prefrontal Lobe Growth in a Patient with Continuous Spike-Waves during Slow Sleep

Prefrontal Lobe Growth in a Patient with Continuous Spike-Waves during Slow Sleep

Reduced Structural Connectivity between Sensorimotor and Language Areas in Rolandic Epilepsy

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

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