Daisuke Hisamatsu, Michiko Ohno-Oishi, Shiho Nakamura, Yo Mabuchi, Hayato Naka-Kaneda
Abstract:The senescence-associated secretory phenotype (SASP) has attracted attention as a mechanism that connects cellular senescence to tissue dysfunction, and specific SASP factors have been identified as systemic pro-aging factors. However, little is known about the age-dependent changes in the secretory properties of stem cells. Young, but not old, mesenchymal stem/stromal cells (MSCs) are a well-known source of critical regenerative factors, but the identity of these factors remains elusive. In this study, we ide…
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