Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma

Zhang, Yan; Shao, Jian Yong; Zhi, Wang; Yang, Tieyi; Shuyi, Liu; Liu, Yue; Fan, Xinbing; Ye, Weiguang

doi:10.1016/j.gene.2014.12.039

Cited by 44 publications

(48 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Using this GDF11-specific immunoassay, we demonstrated that serum GDF11 levels increased with age in elderly Chinese women. Our results were not consistent with the recent study by Zhang et al 12 It is possible that the antibody to GDF11 used in Zhang' study was not specific and that GDF8 was also detected.…”

Section: Developedcontrasting

confidence: 99%

“…7,9 Recently, Zhang reported that GDF11 acts as a protective factor for osteoblastogenesis via inhibition of peroxisome proliferator-activated receptor γ (PPAR-γ) activity. 12 However, Li et al 13 suggested that inhibition of GDF11 activity stimulated bone formation in transgenic mice by increasing osteoblast function. Moreover, Egerman et al 14…”

Section: Dear Editormentioning

confidence: 99%

See 1 more Smart Citation

Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women

Jin

Song

Guo

et al. 2016

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Osteoporosis is an age-related disease. Many studies have confirmed the anti-aging effect of growth differentiation factor 11 (GDF11), but the action of GDF11 on bone metabolism remains unclear. In this study, we aimed to investigate the relationship between serum GDF11 levels and the prevalence of osteoporosis. Our data indicate negative correlations between serum GDF11 levels and BMD at the lumbar spine and femoral neck. The serum GDF11 levels were grouped into quartile intervals, and the prevalence and risk of osteoporosis were found be markedly greater with increased GDF11 levels. This study demonstrated that GDF11 was negatively correlated with BMD in elderly Chinese women. Furthermore, osteoporotic risk was significantly increased with increases in GDF11 levels.

show abstract

Section: Developedcontrasting

confidence: 99%

Section: Dear Editormentioning

confidence: 99%

Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women

Jin

Song

Guo

et al. 2016

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Li et al suggested that inhibition of GDF11 activity stimulates bone formation by increasing osteoblast function. Zhang et al found GDF11 treatment significantly promoted MSC differentiation towards osteoblasts, whereas adipocyte differentiation was inhibited. GDF11 could promote the SUMOylation of PPAR‐γ and decrease its activity as a transcriptional factor, while PPAR‐γ facilitates bone loss by inhibiting osteoblastogenesis and stimulating adipogenesis from bone MSCs .…”

Section: Discussionmentioning

confidence: 99%

“…GDF11 was identified as a circulating age‐associated factor that increased with age in rats and humans . In the past, GDF11 has been proposed to restore skeletal muscle functions and increase bone formation by inhibiting the activity of PPAR‐γ . but a recent study showed that GDF11 had negative effect on muscle and bone regeneration .…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa

et al. 2018

Clinical Endocrinology

View full text Add to dashboard Cite

Background: Adolescents with anorexia nervosa (AN) have low body mass and low bone mineral density (BMD). Growth differentiation factor 8 (Myostatin, GDF8) and its homologue growth differentiation factor 11 (GDF11), members of the TGF-β super-family, play an important role in muscle regeneration and bone metabolism in healthy individuals. However, their association with BMD in AN is unknown. The present study was undertaken to investigate the relationship between GDF8, GDF11 and BMD in adolescent girls with AN.Methods: Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old).Results: Growth differentiation factor 8 levels were lower in AN subjects. On the contrary, GDF11 levels were higher in AN subjects than controls. There was no relationship between GDF8 and BMD. A significant negative correlation between GDF11 and BMD was found. In multiple linear stepwise regression analysis, BMI, 25-hydroxyvitamin D, GDF11, or lean mass, but not fat mass and GDF8, were independent predictors of BMD in the AN and control groups separately.Conclusions: Growth differentiation factor 11 was independent predictor of BMD in girls with AN. It suggested that GDF11 exerts a negative effect on bone mass. K E Y W O R D S anorexia nervosa, bone mineral density, growth differentiation factor 11, growth differentiation factor 8 How to cite this article: Wu Y, Qu J, Li H, et al. Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa. Clin Endocrinol. 2019;90:88-93. https://doi.

show abstract

“…GDF11 є універсальним консервативним чинником розвитку тканин для всіх хребетних [13]. GDF11член чинників росту і диференціювання суперсімейства TGF-β 1 /activin/BMP [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43], що активує сигнальні шляхи SMAD (Similar to Mothers Against Decapentaplegic) і non-SMAD і регулює експресію цільових ядерних генів. GDF11 діє як фактор, необхідний для нормального функціонування ембріонального патерну й органогенезу.…”

Section: загальнобіологічні властивості і біохімічна регуляція Gdf11unclassified

Фактор Диференціації Росту 11: Загальнобіологічні Властивості, Метаболічні Ефекти Та Можлива Патофізіологічна Роль При Артеріальній Гіпертензії, Ожирінні, Цукровому Діабеті Та Залежній Від Віку Патології (Огляд Літератури)

Koval¹,

Miloslavsky²,

Snihurskaya³

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

Резюме. В огляді наведені сучасні літературні дані щодо загальнобіологічних властивостей фактора диференціації росту 11 (GDF11), його участі в ембріогенезі, онкогенезі, ангіогенезі, старінні й апоптозі, відмінностей між GDF11 та міостатином, перспектив призначення рекомбінантного GDF11, експериментальних досліджень ефектів GDF11 на тваринах, можливостей клінічного застосування GDF11, його різнобічної дії при серцево-судинних захворюваннях, участі в тромбогенезі, використання в дієтології, спортивній медицині і трансфузіології, можливостей генної терапії гіпертензивного серця та її потенційних мішеней.

show abstract

Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma

Cited by 44 publications

References 30 publications

Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women

Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women

Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa

Contact Info

Product

Resources

About