Growth Arrest of Epithelial Cells during Measles Virus Infection Is Caused by Upregulation of Interferon Regulatory Factor 1

Fosfomycin Suppresses Chemokine Induction in Airway Epithelial Cells Infected with Respiratory Syncytial Virus

“…The DNA-binding activities of transcription factors in cells were determined by an enzyme-linked DNA-protein interaction assay (ELDIA), essentially by a previously described method (35). Nuclear extracts were prepared with the NE-PER nuclear and cytoplasmic extraction reagents (Pierce, Rockford, IL).…”

“…The luciferase reporter gene assay was carried out as described previously (35). Plasmids containing fragments of the RANTES promoter (Ϫ884 bp to ϩ1 bp) and its mutants were kindly provided by S. Matsukura, Showa University School of Medicine (Tokyo, Japan) (12).…”

Jak Inhibition, but Not Stat1 Knockdown, Blocks the Synergistic Effect of IFN-γ on Fas-Induced Apoptosis of A549 Human Non-Small Cell Lung Cancer Cells

“…Similar finding have been reported by others. 14,15 FACS analysis showed that 10 ng/mL IFN-␥ did not induce marked changes in the cell cycle distribution; however, IFN-␥ did induce a 52% decrease after 48 h in the (G 2 ϩM)/S ratio (p ϭ 0.01; n ϭ 6). These observations are consistent with a slowing of the cell cycle (Fig.…”

Immune Activation at Effector and Gene Expression Levels After Measles Vaccination in Healthy Individuals: A Pilot Study

“…Interferons (␣ and ␤) play a pivotal role in human antiviral innate responses. IFN-␣/␤ mediates its antiviral role via a IFN-regulatory factor-1, which is known to upregulate MHC-II expression in a CIITA-dependent manner [56,57]. The V protein of the measles virus vaccine strain (Edmonston) has been reported to suppress IFN-␣ signaling [58,59].…”