Growth and the growth hormone axis in prepubertal children with asthma

Crowley, Suzanne; Hindmarsh, Peter C.; Matthews, David R.; Brook, C. G. D.

doi:10.1016/s0022-3476(95)70566-x

Cited by 58 publications

(30 citation statements)

References 35 publications

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“…Some studies showed that long-term treatment with glucocorticosteroids in children with asthma children can influence lipid metabolism by increasing the uptake of lipids from the digestive system and enhancing lipids storage in tissues, especially in the trunk (25). However, results of the association between asthma medication treatment and increased risk of obesity have not been consistent (26). Interestingly, our results suggested that asthma rescue medication treatment prevented obesity risk.…”

Section: Discussioncontrasting

confidence: 67%

Effects of Childhood Asthma on the Development of Obesity among School-aged Children

Chen

Salam

Alderete

et al. 2017

Am J Respir Crit Care Med

115

104

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Rationale: Asthma and obesity often occur together in children. It is unknown whether asthma contributes to the childhood obesity epidemic.Objectives: We aimed to investigate the effects of asthma and asthma medication use on the development of childhood obesity.Methods: The primary analysis was conducted among 2,171 nonobese children who were 5-8 years of age at study enrollment in the Southern California Children's Health Study (CHS) and were followed for up to 10 years. A replication analysis was performed in an independent sample of 2,684 CHS children followed from a mean age of 9.7 to 17.8 years.Measurements and Main Results: Height and weight were measured annually to classify children into normal, overweight, and obese categories. Asthma status was ascertained by parent-or self-reported physician-diagnosed asthma.Cox proportional hazards models were fitted to assess associations of asthma history with obesity incidence during follow-up. We found that children with a diagnosis of asthma at cohort entry were at 51% increased risk of developing obesity during childhood and adolescence compared with children without asthma at baseline (hazard ratio, 1.51; 95% confidence interval, 1.08-2.10) after adjusting for confounders. Use of asthma rescue medications at cohort entry reduced the risk of developing obesity (hazard ratio, 0.57; 95% confidence interval, 0.33-0.96). In addition, the significant association between a history of asthma and an increased risk of developing obesity was replicated in an independent CHS sample.Conclusions: Children with asthma may be at higher risk of obesity. Asthma rescue medication use appeared to reduce obesity risk independent of physical activity.

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Section: Discussioncontrasting

confidence: 67%

Effects of Childhood Asthma on the Development of Obesity among School-aged Children

Chen

Salam

Alderete

et al. 2017

Am J Respir Crit Care Med

115

104

View full text Add to dashboard Cite

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“…In humans, glucocorticoid excess has been associated with reduced GH secretion in some studies [36], but not all [37]. The interpretation of these findings is complicated by the presence of the underlying disease requiring glucocorticoid treatment and by the suppressive effect of obesity per se on GH secretion.…”

Section: Glucocorticoidmentioning

confidence: 99%

Endocrine Regulation of the Growth Plate

et al. 2005

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Longitudinal bone growth occurs at the growth plate by endochondral ossification. Within the growth plate, chondrocyte proliferation, hypertrophy, and cartilage matrix secretion result in chondrogenesis. The newly formed cartilage is invaded by blood vessels and bone cells that remodel the newly formed cartilage into bone tissue. This process of longitudinal bone growth is governed by a complex network of endocrine signals, including growth hormone, insulin-like growth factor I, glucocorticoid, thyroid hormone, estrogen, androgen, vitamin D, and leptin. Many of these signals regulate growth plate function, both by acting locally on growth plate chondrocytes and also indirectly by modulating other endocrine signals in the network. Some of the local effects of hormones are mediated by changes in paracrine factors that control chondrocyte proliferation and differentiation. Many human skeletal growth disorders are caused by abnormalities in the endocrine regulation of the growth plate. This review provides an overview of the endocrine signals that regulate longitudinal bone growth, their interactions, and the mechanisms by which they affect growth plate chondrogenesis.

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“…It can be assumed that the mechanisms by which inhaled CrS or ICS influence growth do not involve alteration of GH secretion. 28 The control of linear growth has been related to the additive effects of GH, sex hormones, insulin growth factors and their binding proteins, 5,29 but a discussion of the reciprocal effects of these factors is far beyond the scope of the present study.…”

Section: Discussionmentioning

confidence: 96%