Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis

Konstan, Michael W.; Butler, Steven M.; Wohl, Mary Ellen B.; Stoddard, Marcia L.; Matousek, Robert; Wagener, Jeffrey S.; Johnson, Charles A.; Morgan, Wayne J.

doi:10.1067/mpd.2003.152

Cited by 349 publications

(293 citation statements)

References 22 publications

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“…This can be explained by the parallel decrease in weight as well as height scores. Previous studies have related the development of CFRD to deterioration in lung function [23][24][25]. This relation is confirmed by our results.…”

Section: Discussionsupporting

confidence: 82%

Cystic-fibrosis related-diabetes (CFRD) is preceded by and associated with growth failure and deteriorating lung function

Terliesner¹,

Vogel

Steighardt³

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Impaired glucose metabolism and cystic fibrosis (CF)-related diabetes (CFRD) are associated with insufficient weight gain and impaired lung function in children and adolescents with CF. We have asked whether imminent CFRD may be a cause of poor growth in children and adolescents. Methods: A retrospective case control study including 32 patients with CF with or without diabetes was conducted. Sixteen pairs, matched according to age, gender and exocrine pancreatic insufficiency, were analysed. Standard deviation scores (SDS) of height, growth, weight, body mass index (BMI), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and forced expiratory flow at 75% of expired FVC (FEF75) were recorded during a mean observation period of 13 years per patient. Results: SDS of height and weight were reduced in CF patients with diabetes compared to those without, not only at the point of diagnosis (both p < 0.05) but years before the evidence of diabetes. Afterwards there was a significant decline in height (p < 0.001) and weight (p < 0.01) SDS in CFRD patients and an increasing difference between the height and weight of CF patients with or without diabetes. In contrast, no significant reduction of BMI-SDS was observed in CFRD patients. All analysed lung function parameters showed a marked decline in CFRD patients starting 1 year prior to the diagnosis of diabetes. Conclusions: Deteriorating growth, reduced weight and impaired lung function are related to the development of CFRD and are obvious several years before the actual diagnosis of diabetes.

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Section: Discussionsupporting

confidence: 82%

Cystic-fibrosis related-diabetes (CFRD) is preceded by and associated with growth failure and deteriorating lung function

Terliesner¹,

Vogel

Steighardt³

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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“…Konstan et al13 examined, in 931 patients, the relative role of growth and nutritional status and the clinical evidence of lung disease from age 3-6 years in determining pulmonary function at 6 years of age. The results showed that mean WFA and HFA at both ages 3 and 6 years were below the 50th percentile for healthy children.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies12 , 13 , 18 reported that the improvement of both growth and clinical parameters in early life was associated with a better lung function 2-5 years later. Thus, it is suggested that growth and nutritional status in childhood may be strong predictors of the severity of lung disease later in life, which is reinforced by Yen et al,16 who showed that patients in the highest weight and height percentiles at age 4 years had fewer pulmonary exacerbations, spent fewer days in the hospital, and had better survival at age 18 years.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the start up period of each study, the age range of the patients was 0-15.3 years old. According to the study design, one was a cohort study,12 four were longitudinal studies13 - 15 , 17 and two were prospective studies 1618 …”

Section: Data Synthesismentioning

confidence: 99%

“…Among the nutritional and growth parameters, Body Mass Index (BMI) was evaluated in five studies,12 , 14 - 16 , 18 height alone was evaluated in two studies,13 , 15 height gain was evaluated in two studies,13 , 15 Weight For Age (WFA) was evaluated in two studies,14 , 18 Height For Age (HFA) was evaluated in two studies 1416 The remaining parameters were evaluated each one in one study: weight alone,14 percent of height-appropriate Body Weight (%haBW),12 percentage of the Ideal Body Weight (%IBW),12 Height for Age Z -score (HAZ),12 Weight for Age Z -score (WAZ),12 Height-For-Age adjusted for Target Height (HFA/TH),17 Weight-For-Length and BMI percentiles (WFL-BMI)18 (Tables 1 and 2).…”

Section: Data Synthesismentioning

confidence: 99%

See 2 more Smart Citations

Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

Mauch

Kmit

Marson

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:To review the literature addressing the relationship of growth and nutritional parameters with pulmonary function in pediatric patients with cystic fibrosis.Data source:A collection of articles published in the last 15 years in English, Portuguese and Spanish was made by research in electronic databases - PubMed, Cochrane, Medline, Lilacs and Scielo - using the keywords cystic fibrosis, growth, nutrition, pulmonary function in varied combinations. Articles that addressed the long term association of growth and nutritional parameters, with an emphasis on growth, with pulmonary disease in cystic fibrosis, were included, and we excluded those that addressing only the relationship between nutritional parameters and cystic fibrosis and those in which the aim was to describe the disease.Data synthesis:Seven studies were included, with a total of 12,455 patients. Six studies reported relationship between growth parameters and lung function, including one study addressing the association of growth parameters, solely, with lung function, and all the seven studies reported relationship between nutritional parameters and lung function.Conclusions:The review suggests that the severity of the lung disease, determined by spirometry, is associated with body growth and nutritional status in cystic fibrosis. Thus, the intervention in these parameters can lead to the better prognosis and life expectancy for cystic fibrosis patients.

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Randomized Clinical Trial of Behavioral Intervention and Nutrition Education to Improve Caloric Intake and Weight in Children With Cystic Fibrosis

Stark¹,

Quittner²,

Powers³

et al. 2009

Arch Pediatr Adolesc Med

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Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis

Cited by 349 publications

References 22 publications

Cystic-fibrosis related-diabetes (CFRD) is preceded by and associated with growth failure and deteriorating lung function

Cystic-fibrosis related-diabetes (CFRD) is preceded by and associated with growth failure and deteriorating lung function

Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

Randomized Clinical Trial of Behavioral Intervention and Nutrition Education to Improve Caloric Intake and Weight in Children With Cystic Fibrosis

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