“…Nonmechanical factors, such as hormones and growth factors, also act to guide this mechanism, as does the regulation by epigenetic, extragenetic and genetic influences (Frost, 1998; Skedros et al, 2007). There is a growing understanding of how the juvenile skeleton responds to changing forces, however, this remains an area of active research with gaps within the knowledge remaining (Ryan et al, 2017; Saers et al, 2022).…”