Growth and development of Amphibia as affected by thyroidectomy

Hoskins, E. R.; Hoskins, Margaret M.

doi:10.1002/jez.1400290102

Cited by 80 publications

(17 citation statements)

References 8 publications

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“…The values for FT 4 and FT 3 shown in Table 3 display the same general trend as the values for total T 4 and T3 shown in Fig. 2.…”

Section: Free T 4 and Free T 3 Levels In Plasma From R Catesbeiana Tsupporting

confidence: 54%

“…The very low levels of circulating T 4 and T.i both in premetamorphosis tadpoles and in adults suggest that thyroid hormones in anuran Amphibia may be of importance only during the period of metamorphosis. (Endocrinology 102: 674,1978) "^HE EXPERIMENTS of Gudernatsch (1, . 2), Allen (3), and Hoskins and Hoskins (4) in the early part of this century established that amphibian metamorphosis is dependent on thyroid hormone. These findings implied that metamorphic changes in tadpoles should be preceded by increases in the level of circulating thyroid hormone.…”

mentioning

confidence: 98%

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Plasma Thyroxine and Triiodothyronine Levels in Spontaneously Metamorphosing Rana catesbeiana Tadpoles and in Adult Anuran Amphibia*

1978

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We have developed sensitive and reliable radioimmunoassays for T4 and T3 in amphibian plasma and have used these procedures to measure plasma T4 and T3 levels in spontaneously developing Rana catesbeiana tadpoles at various stages of metamorphosis. During premetamorphosis circulating levels of both T4 and T3 were below the limits of detection of the RIA procedures (T4 less than 50 ng/100 ml, T3 less than 5 ng/100 ml). A gradual rise in plasma T3 and T4 became apparent during prometamorphosis, and at the onset of metamorphic climax the levels of both T4 and T3 increased sharply. Peak levels for both hormones were observed in the middle of metamorphic climax (stage XXIII). The circulating T3 level reached a mean peak of 78 ng/100 mg, at least 15 times greater than the level during premetamorphosis. The peak T4 level was 0.5 microgram/100 ml, about a 10-fold increase over the premetamorphosis level. The surge in thyroid hormone secretion lasted only for several days, and during the latter half of metamorphic climax there was a fairly rapid decrease in plasma T4 and T3. By 2 days post-climax the levels had declined to about 20% of their peak values. Free T4 and T3 levels in plasma followed the same general pattern as the total hormone levels during the various stages of tadpole development. In adult R. catesbeiana, plasma T4 and T3 levels were surprisingly low. Similarly low values were observed in Bufo marinus and in Rana pipiens. The very low levels of circulating T4 and T3 both in premetamorphosis tadpoles and in adults suggest that thyroid hormones in anuran Amphibia may be of importance only during the period of metamorphosis.

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“…The values for FT 4 and FT 3 shown in Table 3 display the same general trend as the values for total T 4 and T3 shown in Fig. 2.…”

Section: Free T 4 and Free T 3 Levels In Plasma From R Catesbeiana Tsupporting

confidence: 54%

mentioning

confidence: 98%

Plasma Thyroxine and Triiodothyronine Levels in Spontaneously Metamorphosing Rana catesbeiana Tadpoles and in Adult Anuran Amphibia*

1978

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“…GUDERNATSCH (1912) clearly showed that feeding thyroid substance (extract from mammalian thyroid) to larval frogs remarkably alters their growth processes and hastens metamorphosis (SCHNEIDER, 1939). The thyroid anlage is removed from young embryos and the thyroidless larvae do not metamorphose after metamorphosis of the control or even when keep alive for a year (HOSKINS and HOSKINS, 1919;HOSKINS, 1922;ALLEN, 1916ALLEN, , 1938. LYNN and BRAMBEL (1935) reported that if iodine is absent from the environment and diet, metamorphosis is not initiated and animals thrive beyond the normal period of larval life.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural and Cytochemical Studies on the Thyroid Gland of Normal Metamorphosing Frogs (<i>Rana japonica</i> Guenther)

Nanba

1972

Arch. Histol. Jap., Arch. Histol. Jpn

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“…Early investigations by Gudernatsch (1912) and Hoskins and Hoskins (1919) demonstrated that anuran metamorphosis is dependent upon thyroid hormones. Etkin ( 1935,1964) found that thyroidectomized tadpoles, which are unable to metamorphose, begin to undergo metamorphosis when they are placed in water containing known concentrations of thyroxine.…”

Section: Introductionmentioning

confidence: 99%

Immunoreactive thyroxine levels in the serum of thyroidectomized adult newts, Notophthalmus viridescens

Liversage¹,

Foty²,

McLaughlin³

1988

Can. J. Zool.

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The concentration of immunoreactive thyroxine was determined in blood serum samples from thyroidectomized adult newts (Notophthalmus viridescens) relative to levels found in samples of serum from intact and sham-thyroidectomized newts by means of radioimmunoassay. The results show a significant rate and degree of decline in the level of thyroxine from 24 h to 14 days post-thyroidectomy, followed by further reductions of the immunoreactive thyroxine levels between 14 and 35 days, as compared with levels in intact and sham-thyroidectomized controls.

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Growth and development of Amphibia as affected by thyroidectomy

Cited by 80 publications

References 8 publications

Plasma Thyroxine and Triiodothyronine Levels in Spontaneously Metamorphosing Rana catesbeiana Tadpoles and in Adult Anuran Amphibia*

Plasma Thyroxine and Triiodothyronine Levels in Spontaneously Metamorphosing Rana catesbeiana Tadpoles and in Adult Anuran Amphibia*

Ultrastructural and Cytochemical Studies on the Thyroid Gland of Normal Metamorphosing Frogs (<i>Rana japonica</i> Guenther)

Immunoreactive thyroxine levels in the serum of thyroidectomized adult newts, Notophthalmus viridescens

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