Growth and Development in White Patients with Sickle Cell Diseases

Caruso-Nicoletti, Manuela; Mancuso, M.; Spadaro, Giorgio; Samperi, Piera; Consalvo, C.; Schilirò, Gino

doi:10.1097/00043426-199211000-00002

Cited by 14 publications

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“…Moderate growth delay was reported in 76 white Sicilian children (1-17 yrs) with SCD. 59 Weight and height were ,3rd centile of reference values for white British children in 16% and 10.5%, respectively. The majority had Benin haplotypes and showed no growth differences compared with b-S thalassaemia.…”

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confidence: 90%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

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confidence: 90%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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“…Caruso-Nicoletti et al reported means of both weight and height to be 1 s.d. below the normal mean for age in 31 children with sickle-cell anaemia and 83 patients with thalassaemia (Caruso-Nicoletti et al, 1992). Micronutrient de®ciencies are also common in children with thalassaemia (Uysal et al, 1993;Benso et al, 1995).…”

Section: Indications For Bone Marrow Transplantation As Determinants mentioning

confidence: 99%

Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral de®ciencies are all common following transplantation and have profound nutritional consequences. Malnutrition affects negatively the clinical outcome. Nutritional support is provided to malnourished patients and those who suffer deterioration in nutritional status despite the provision of dietetic counselling. Only a few randomised studies comparing enteral with parenteral nutrition after transplant exist. Both enteral tube feeding (in the absence of mucositis) and parenteral nutrition are effective in maintaining nutritional status. However, enteral nutrition is associated with a better nutritional response and fewer complications than parenteral. With existing enteral and parenteral nutrition regimens close monitoring of trace element and mineral status is required.

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2001

The Thalassaemia Syndromes

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Growth and Development in White Patients with Sickle Cell Diseases

Cited by 14 publications

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Growth and nutritional status of children with homozygous sickle cell disease

Growth and nutritional status of children with homozygous sickle cell disease

Nutritional considerations in children undergoing bone marrow transplantation

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