Growth and development in infants after renal transplantation

So, Samuel; Chang, Pi-Nian; Najarian, J. S.; Mauer, S. Michael; Simmons, Richard L.; Nevins, Thomas E.

doi:10.1016/s0022-3476(87)80491-2

Cited by 77 publications

(19 citation statements)

References 20 publications

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“…22 This supports other findings of compromised development attributable to chronic illness per se,1-4 35 36 with gross motor and language development being affected particularly 1437 The impact on development of chronic illness in general, rather than specific diagnoses, is further supported by the failure to find differences preoperatively between children with cyanotic lesions and those with acyanotic lesions.…”

Section: Discussionsupporting

confidence: 71%

Controlled study of preschool development after surgery for congenital heart disease

Wray

Sensky²

1999

Archives of Disease in Childhood

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Aim-Research into intellectual impairment among children with congenital heart disease has focused mainly on older children. This study was designed to determine whether previous findings are applicable to preschool children. Methods-Three groups of children under 3 1 ⁄2 years old were assessed immediately before treatment and 12 months later: a group with congenital heart disease awaiting surgery, another awaiting bone marrow transplantation, and a healthy comparison group. Results-Although the means of the three groups were within the normal range, preoperatively the cardiac and transplant groups showed deficits compared with the healthy controls. Postoperatively, continuing developmental deficits were significant only in the children with cyanotic lesions. Conclusions-Conclusions about intellectual development in older children with congenital heart disease do not apply to preschool children. Before corrective surgery, chronic illness itself appears to be the predominant influence on development. Postoperatively, cyanotic and acyanotic lesions are associated with different short term outcomes. (Arch Dis Child 1999;80:511-516)

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Section: Discussionsupporting

confidence: 71%

Controlled study of preschool development after surgery for congenital heart disease

Wray

Sensky²

1999

Archives of Disease in Childhood

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“…Finally, it is likely that the developmental outcome of our patients, as well as those of Honda et al [9] benefited from the receipt of a renal allograft [38][39][40][41]. As previously demonstrated, a successful kidney transplant likely leads to cognitive improvement by correcting factors that interfere with optimal mental and motor functioning, and therefore providing a healthy milieu for the developing brain.…”

Section: Discussionmentioning

confidence: 84%

Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy

Warady

Belden

Kohaut

1999

Pediatric Nephrology

114

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A retrospective review of 34 infants who started long-term peritoneal dialysis at 1 year and who underwent a formal neurodevelopmental evaluation. In addition to dialysis, treatment of the patients included the use of calcium carbonate as the sole phosphate binder in all patients and supplemental nasogastric tube feeding in 27. At 1 year of age, the 28 patients had a mean head circumference standard deviation score of -0.96+/-1.2. The mental developmental score of 22 (79%) patients fell in the average range, while only 1 (4%) child was significantly delayed. Of 19 children retested at >/=4 years of age, 15 (79%) performed in the average range and 1 (5%) performed in the impaired range. Of 16 patients >/=5 years of age, 15 (94%) attended school full time and in age-appropriate classrooms. Twenty-four patients received their initial kidney transplant at a mean age of 2.1+/-0.8 years. This experience provides evidence that the combination of aggressive nutrition, the elimination of aluminum as a phosphate binder, the provision of dialysis, and subsequent transplantation all contribute to a favorable developmental outcome in infants who develop end-stage renal disease in early infancy.

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“…In renal replacement therapy transplantation is regarded as the best way to improve the statural growth [4,5] as well as the final height [6,7]. Unfortunately, not all children receiving transplants exhibit sufficient growth velocity after grafting; the reasons for this have been discussed controversially in the past.…”

Section: Introductionmentioning

confidence: 99%

Growth after renal transplantation: an update

1991

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Several factors influencing post-transplant growth were analysed in a total of 163 children receiving transplants at the Medical School Hannover. Statural height at the time of transplantation depended on the length of the pre-transplant period of chronic renal failure, and was more retarded in children with congenital renal diseases than in those with acquired diseases. The retardation of bone age correlated significantly with the degree of growth retardation. The immunosuppressive regimen of cyclosporine A (CyA) and low-dose prednisolone was followed by significantly better growth rates than azathioprine (Aza) plus high-dose prednisolone. In 22 prepubertal children receiving CyA, poor graft function with a glomerular filtration rate below 40 ml/min per 1.73 m2 inhibited catch-up growth. The final height of 20 grown-up transplant recipients was found to be in the lower range of normal. A comparison of conventional and CyA treatment showed that adult height in the CyA group was higher than in the Aza group due to a significantly higher growth velocity.

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Growth and development in infants after renal transplantation

Cited by 77 publications

References 20 publications

Controlled study of preschool development after surgery for congenital heart disease

Controlled study of preschool development after surgery for congenital heart disease

Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy

Growth after renal transplantation: an update

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