Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation—a report of two cases

Glass, Torin; Cochrane, D. Douglas; Rassekh, Shahrad R.; Goddard, Karen; Hukin, Juliette

doi:10.1007/s00381-013-2295-1

Cited by 14 publications

(15 citation statements)

References 14 publications

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“…Glass et al . described two cases in which residual intracranial teratomas of GTS developed malignant transformation three to four years after the initial surgery . In our case, the angiosarcoma component may have been present before chemotherapy, despite elevated serum tumor marker levels and CT‐guided core needle biopsy indicating combined NSGCT.…”

Section: Discussionmentioning

confidence: 65%

“…Malignant transformation of NSGCT reflects a germ cell tumor with somatic‐type malignancy that is accompanied by a non‐germ cell malignant sarcoma or carcinoma component . The cause of the malignant transformation remains unclear, although it is associated with teratomatous components or residual teratoma of GTS . Glass et al .…”

Section: Discussionmentioning

confidence: 99%

“…Non‐germinal tumors, such as sarcoma or adenocarcinoma, are rare but well described in NSGCTs that involve a “somatic‐type” malignancy or transformation. Residual teratoma from GTS carries a risk of malignant transformation . Furthermore, giant mediastinal tumors are challenging to resect based on the limited operative field and rich local blood supply .…”

Section: Introductionmentioning

confidence: 99%

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Development of angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy

et al. 2018

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Herein, we report a case of an angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. A 26‐year‐old man presented with a giant anterior mediastinal mass, which was diagnosed as a non‐seminomatous germ cell tumor. The patient was administered three cycles of chemotherapy (bleomycin, etoposide, and cisplatin), but the mass grew despite normalization of tumor markers. Massive bleeding during thoracic surgery resulted in incomplete resection, and the mass was clinically and pathologically diagnosed as growing teratoma syndrome (only mature teratoma). The residual mass continued to grow, and complete resection was subsequently achieved after a detailed analysis of its vascular anatomy using angiography. The final pathological findings revealed angiosarcoma, which indicated a rare somatic type of mediastinal non‐seminomatous germ cell tumor.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy

et al. 2018

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“…These include interferon and radiation. Radiation is a standard treatment of nongerminomatous germ cell tumors but was not utilized in this case due to normalization of tumor markers and concern for the development of malignant transformation of the residual teratoma . Radiation may be necessary in the future pending his clinical course.…”

Section: Discussionmentioning

confidence: 99%

PD0332991 (Palbociclib) for treatment of pediatric intracranial growing teratoma syndrome

Schultz

Petronio

Bendel

et al. 2014

Pediatric Blood & Cancer

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Growing teratoma syndrome is characterized by growth of mature teratoma elements of a mixed germ cell tumor despite resolution of immature/malignant elements with administration of chemotherapy. Surgical resection is the only known cure for growing teratoma syndrome but in the brain, complete resection may be impossible. In these instances, mature teratoma, although histologically benign, may be fatal. In this report, we present the case of a child with a large, rapidly growing, unresectable pineal region growing teratoma. PD0332991 was administered with stabilization of the solid, enhancing components of the mass. Minimal adverse effects were noted.

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“…2 Although RMS is a very rare form of cancer, it is the most common pediatric sarcoma primarily affecting children before the age of 5, yet is very rare in adults. 3 From the year 2006 to 2010 there has been 295 cases of children diagnosed with RMS in Canada, with 43 mortalities from the year 2008 to 2012. 4 RMS is 1.4 times more likely in males than females, and it is not different among different races of ethnicities.…”

Section: Introductionmentioning

confidence: 99%

Biologic and Clinical Aspects of Rhabdomyosarcoma

Emami¹,

Sepehri²,

Gordon³

et al. 2017

Int J Basic Sci Med

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Rhabdomyosarcoma (RMS) is a muscle-derived tumor and is the most common pediatric soft tissue sarcoma representing 5% of all childhood cancers. Statistically, soft tissue sarcomas account for approximately 10% of all cancers in children, of which more than half of these tumors are RMS. Thus, RMS is a major clinical problem in pediatric oncology. RMS is caused by a disruption in the pathway of primitive mesenchymal stem cells directed towards myogenesis. In most cases of patients diagnosed with RMS there is a genetic or chromosomal alteration involved. In past few years there have been discoveries of more therapeutic approaches that has improved the quality of life in RMS patients and has resulted in a better survival rate in this population from 25% to 60%. However, Additional researches and clinical trials are needed in order to minimize the devastating consequences of the pediatric cancer including RMS. In the current mini review we will briefly discuss current knowledge in RMS focusing on most common biological and clinical aspects of the disease.

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Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation—a report of two cases

Cited by 14 publications

References 14 publications

Development of angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy

Development of angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy

PD0332991 (Palbociclib) for treatment of pediatric intracranial growing teratoma syndrome

Biologic and Clinical Aspects of Rhabdomyosarcoma

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