Growing teratoma syndrome: Clinical and radiographic characteristics

Abstract

Abbreviations & AcronymsObjectives: To present an overview of our surgical experience in the management of growing teratoma syndrome. Methods: A retrospective analysis of all patients undergoing post-chemotherapy retroperitoneal lymphadenectomy between November 2005 and February 2012 revealed 15 patients who met the criteria for growing teratoma syndrome. Their clinical data, imaging characteristics, and surgical and oncological outcomes were reviewed. Results:The median age at diagnosis was 23 years. Primary testis tumors included nonseminomatous germ cell tumor in 12 of 15 patients, seminoma in two of 15 patients and hemorrhagic mass in one patient. Mature teratoma was present in just six (40%) of the orchiectomy specimens. All patients received preoperative chemotherapy. On imaging, the median size of the largest retroperitoneal mass was 7 cm (range 3.9-24.5 cm). The median rate of linear growth was 0.5 cm/month (range 0.03-2.9), and the increase in volume was 9.2 cm 3 /month. All tumors were found to have cystic and necrotic components. Median operative time was 6.2 h (range 4.2-15.2 h). Estimated blood loss was 600 mL (range 100-7000 mL), and median length of stay was 5 days (range 3-19 days). Four patients required resection of non-retroperitoneal growing teratoma masses after post-chemotherapy retroperitoneal lymphadenectomy to achieve tumor-free status. There were two minor (Clavien I-II) and two major postoperative complications (Clavien ≥III). All patients are alive and disease free with a median duration of follow-up of 8 months (range 1-64 months). Conclusions: Growing teratoma syndrome tumors vary in their growth rate, but they all appear to have cystic features with necrosis elements on radiographic evaluation. Aggressive surgical excision is associated with excellent outcomes.

Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl

“…Growing teratomas have a rapid expansion rate, with a median linear growth of 0.5 to 0.7 cm/month and volume increase of 9.2 to 12.9 cm 3 /month. 11,12 While from the results of our study, the tumor growth was 0.94 cm/month (range 0.3–4.3 cm/month, n = 21) (Table 1  ). The discrepancy could be explained by different sample sizes.…”

Editorial Comment to Growing teratoma syndrome: Clinical and radiographic characteristics

“…The present study by Lee et al . describes the clinical, radiographic and surgical characteristics of GTS from two academic medical centers with expertise in the type of major surgery typically involved in the treatment of GTS . The small number of patients ( n = 15) treated during this 7‐year period attests to the rarity of this entity, which was similarly observed by Spiess et al .…”

Recurrence of immature ovarian teratoma as malignant follicular carcinoma with liver and peritoneal metastasis 22 years after completion of initial treatment

“…On imaging, GTS tumours demonstrate cystic components with necrosis, although tumour growth is the only consistent feature of GTS. A median growth rate of 0.5 cm/month in GTS has been reported 6. Although the liver is an atypical site for GTS, the appearance of mature cystic teratoma in the liver has previously been reported in two patients with immature ovarian tumours undergoing chemotherapy 7…”