SMART business development is studied through indicators of geopolitical and geoeconomical changes via the example of Cherkasy oblast (the central region ofUkraine) in order to determine the strategy of regional business improvement using global political and economic priorities. Cherkasy oblast was selected for the study because it is one of the pilot regions for implementation of the SMART business strategies.The following methods were used in the course of the study: the system-structure analysis, spatial-comparative method, interpolation, correlation as well as descriptionstatistical method.The proposed results of the study may be used in Ukraine as well as in the countries of the Eastern Partnership for development of effective strategy for SMART business improvement. The results of the study are intended for national and regional SMART businesspolicy, optimisation of SMART specialisation forrepresentatives of medium and small business, researchers dealing with regional development problems etc.