Growing applications of FDG PET-CT imaging in non-oncologic conditions

Zhuang, Hongming; Codreanu, Ion

doi:10.7555/jbr.29.20140081

Cited by 51 publications

(19 citation statements)

References 93 publications

(112 reference statements)

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“…Clinical applications of PET with FDG are not limited to the area of oncology, because FDG can accumulate at the sites of infection and inflammation owing to increased glycolytic activity in these states 29 . Examples include mononuclear cells such as lymphocytes and macrophages, which consume large amounts of glucose when targeting a source of an infection.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

Towards clinically translatable in vivo nanodiagnostics

et al. 2017

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Nanodiagnostics as a field makes use of fundamental advances in nanobiotechnology to diagnose, characterize and manage disease at the molecular scale. As these strategies move closer to routine clinical use, a proper understanding of different imaging modalities, relevant biological systems and physical properties governing nanoscale interactions is necessary to rationally engineer next-generation bionanomaterials. In this Review, we analyse the background physics of several clinically relevant imaging modalities and their associated sensitivity and specificity, provide an overview of the materials currently used for in vivo nanodiagnostics, and assess the progress made towards clinical translation. This work provides a framework for understanding both the impressive progress made thus far in the nanodiagnostics field as well as presenting challenges that must be overcome to obtain widespread clinical adoption.

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Section: Imaging Modalitiesmentioning

confidence: 99%

Towards clinically translatable in vivo nanodiagnostics

et al. 2017

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“…An estimated 3 million PET/CT procedures were performed in the United States in 2017, with over 90% being for oncology care and approximately 10% for assessing myocardial perfusion, neurologic function, and other physiologic processes (1,2). Complete delivery of an intravenous bolus of radiotracer is important to the accuracy and reproducibility of imaging (3) and thus to patient treatment (4).…”

mentioning

confidence: 99%

Quality Improvement Initiatives to Assess and Improve PET/CT Injection Infiltration Rates at Multiple Centers

Wong

Benefield

Masters

et al. 2019

J. Nucl. Med. Technol.

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PET/CT radiotracer infiltration is not uncommon and is often outside the imaging field of view. Infiltration can negatively affect image quality, image quantification, and patient management. Until recently, there has not been a simple way to routinely practice PET radiopharmaceutical administration quality control and quality assurance. Our objectives were to quantify infiltration rates, determine associative factors for infiltration, and assess whether rates could be reduced at multiple centers and then sustained. Methods: A “design, measure, analyze, improve, and control” quality improvement methodology requiring novel technology was used to try to improve PET/CT injection quality. Teams were educated on the importance of quality injections. Baseline infiltration rates were measured, center-specific associative factors were analyzed, team meetings were held, improvement plans were established and executed, and rates remeasured. To ensure that injection-quality gains were retained, real-time feedback and ongoing monitoring were used. Sustainability was assessed. Results: Seven centers and 56 technologists provided data on 5,541 injections. The centers’ aggregated baseline infiltration rate was 6.2% (range, 2%–16%). On the basis of their specific associative factors, 4 centers developed improvement plans and reduced their aggregated infiltration rate from 8.9% to 4.6% (P < 0.0001). Ongoing injection monitoring showed sustainability. Significant variation was found in center- and technologist-level infiltration rates (P < 0.0001 and P = 0.0020, respectively). Conclusion: A quality improvement approach with new technology can help centers measure infiltration rates, determine associative factors, implement interventions, and improve and sustain injection quality. Because PET/CT images help guide patient management, the monitoring and improvement of radiotracer injection quality are important.

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“…Fluorodeoxyglucose (FDG) PET/CT indicates the tissue glucose metabolic rate, and thus, when it is performed for trauma-related arthritis, it mainly reflects the inflammatory process in the soft tissue in the joint [ 21 ]. However, FDG uptake is not sensitive for detection of bone formation or periosteal bone reaction.…”

Section: Discussionmentioning

confidence: 99%

Use of 18F-sodium fluoride bone PET for disability evaluation in ankle trauma: a pilot study

et al. 2018

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BackgroundThere are no objective and accurate rating tools for permanent impairment of traumatized ankles. The purpose of this study is to assess the role of 18F-Sodium fluoride (18F-NaF) positron emission tomography-computed tomography (PET/CT) bone scans in evaluating patients with limited ankle range of motion (ROM) after trauma.Methods18F-NaF PET/CT was performed in 121 patients (75 men, 46 women; mean age: 45.8) who had ROM < 70% of normal after trauma affecting ankles. Metabolic target volume (MTV), the sum of voxels with standardized uptake value (SUV) > 2.5 was automatically obtained from the 3D volume that included the ankle joint. The maximum & mean SUV (SUVmax & SUVmean), and the total lesion activity (TLA) were measured.ResultsThe median period from injury to performing 18F-NaF PET/CT was 290 days. The causes of injury were as follows: fracture (N = 95), Achilles tendon rupture (N = 12), and ligament injury (N = 12). Hot uptake in the ankle was seen in 113 of 121 patients. The fracture group had higher SUVmax, SUVmean, and TLA values than the non-fracture group. More limited ROM correlated with higher hot-uptake parameters (SUVmax, SUVmean, TLA). In subgroup analysis, the same correlations were present in the fracture, but not in the non-fracture group.Conclusions18F-NaF PET/CT can provide considerable information in impairment evaluations of limited ankle ROM, particularly in fracture around the ankle. Thus, 18F-NaF bone PET/CT may provide an additional option as an objective imaging tool in disability assessment after ankle injury.

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Growing applications of FDG PET-CT imaging in non-oncologic conditions

Cited by 51 publications

References 93 publications

Towards clinically translatable in vivo nanodiagnostics

Towards clinically translatable in vivo nanodiagnostics

Quality Improvement Initiatives to Assess and Improve PET/CT Injection Infiltration Rates at Multiple Centers

Use of 18F-sodium fluoride bone PET for disability evaluation in ankle trauma: a pilot study

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