Grover's disease (transient acantholytic dermatosis) associated with atopy

Rosina, Paolo; Melzani, G; Marcelli, Mauro; Zakaria, Wael N.; Colato, Chiara; Barba, Annalisa

doi:10.1111/j.1468-3083.2004.01129.x

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…Furthermore, recent literature data have revealed that Grover's disease may occur in patients with COVID-19 disease, but it is still unknown what the exact role of a new coronavirus is in the etiology of Grover's disease [24]. In our case report, it is of special significance to point to the possibility of association of Grover's disease and atopic dermatitis, which is consistent with the literature data [25,26]. Our patient had eosinophilia, elevated serum immunoglobulin E levels of 700 IU/ml and pruritic erythematous plaques on the eyelids, in cubital and popliteal region with a marked skin xerosis of the whole body.…”

Section: Discussionsupporting

confidence: 90%

Grover’s disease in a patient with atopic dermatitis - a case report

et al. 2021

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Introduction. Grover?s disease is characterized by pruriginous polymorphic rash with a variable course and duration. Although the etiology is still unknown, the disease is often associated with other dermatoses, malignant diseases, use of certain medications, as well as immunosuppression. Case Report. We report a case of a 70-year-old male patient who was referred for examination to the Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, due to a rash that lasted for nine months. The first lesions on the skin appeared around the nipples as exudative eczematous plaques. A few months later, identical lesions appeared on the lower legs. During treatment with systemic antihistamines and topical corticosteroids, there were episodes of transient improvements and re-exacerbations. In the meantime, erythematous brownish, round and oval papules appeared on the abdomen and the back, accompanied by intense itch. Laboratory findings revealed eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of the back lesion was performed and the histopathological examination confirmed the diagnosis of Grover?s disease. After the systemic treatment using corticosteroids and antihistamines, with gradual dose reduction and application of topical corticosteroids and emollients, complete regression of the skin lesions was achieved. Conclusion. Since the clinical manifestations of the disease may be nonspecific and discrete, dermatopathological analysis is of crucial importance in making the correct diagnosis. In patients with atopy, the treatment with systemic corticosteroids, antihistamines and topical agents may lead to regression of skin lesions with a significant improvement in the quality of life.

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Section: Discussionsupporting

confidence: 90%

Grover’s disease in a patient with atopic dermatitis - a case report

et al. 2021

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“…A total of 95 cases reporting treatments and therapeutic efficacy were identified (Figure 2). Topical corticosteroids (TCSs) were the treatment that was most employed for GD (52 out of 95, 56 % of the patients receiving treatment), either alone (44, 46 %) or in association with other topical treatments (8, 8 %), including topical calcineurin inhibitors (tacrolimus ointment 0.1 %), antibiotics (erythromycin 2 % or clindamycin 1 %) or retinoids (tretinoin 0.05 %) [12]. All potency classes were employed among TCSs; triamcinolone acetonide 0.1 % cream was the most used.…”

Section: Treatmentsmentioning

confidence: 99%

“…In some cases, these lesions were reported as pseudoherpetic (9, 3 %) [9]. Rare descriptions included pustules (2 %), bullae (1 %), erythematous plaque-like lesions (1 %) and nodules [9][10][11][12]. Pruritus of variable intensity was a feature in 238 patients (75 %).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Clinical features and treatments of transient acantholytic dermatosis (Grover’s disease): a systematic review

Bellinato

Maurelli

Gisondi

et al. 2020

J Deutsche Derma Gesell

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Summary Grover's disease (GD) is an itchy acantholytic disorder occurring on the trunk of middle‐aged men. Based on the best evidence, this study aimed to provide a summary of the clinical characteristics, disease course and treatments of GD. A systematic review was performed according to PRISMA guidelines for original articles published between 01.01.1970–08.15.2019, assessing clinical features and/or any type of intervention for GD. A total of 263 articles were retrieved, and 116 original reports that were deemed relevant and satisfied the inclusion criteria were included in the analysis (88 case reports, 26 case series and two retrospective reviews). From these articles, 317 patients were identified, with a male‐to‐female ratio of 3.95. The mean age was 59 years (range 11–92). Typical lesions were itchy papules and vesicle‐papules, generally located on the trunk. Spontaneous resolution within one week to eight months was described in 42 % of cases. Topical corticosteroids (TCSs) were the most frequent treatment (response rate of 70 %) followed by systemic retinoids and corticosteroids with response rates of 86 % and 64 %, respectively. According to the results of this review, TCS appears to be the most frequently employed treatment, and we suggest TCS as first‐line therapy. Second‐line treatments could include systemic retinoids or systemic corticosteroids.

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“…Es wurden insgesamt 95 Fälle identifiziert, bei denen über Therapien und therapeutische Wirksamkeit berichtet wurde (Abbildung 2). Die häufigste bei MG eingesetzte Therapiemodalität waren topische Kortikosteroide (TCS) (52 von 95, 56 % der behandelten Patienten), entweder als Monotherapie (44, 46 %) oder in Kombination mit anderen topischen Therapien (8, 8 %), einschließlich topischen Calcineurininhibitoren (Tacrolimus-Salbe 0,1 %), Antibiotika (Erythromycin 2 % oder Clindamycin 1 %) oder Retinoiden (Tretinoin 0,05 %) [12]. Bei den TCS wurden alle Wirksamkeitsklassen eingesetzt; am häufigsten kam Triamcinolonacetonid-Creme 0,1 % zum Einsatz.…”

Section: Behandlungenunclassified

“…In einigen Fällen wurden die Läsionen als pseudoherpetisch beschrieben (9,3 %) [9]. Selten beschrieben wurden Pusteln (2 %), Bullae (1 %), erythematöse plaqueartige Läsionen (1 %) und Knoten [9][10][11][12]. 238 Patienten (75 %) litten an Pruritus unterschiedlicher Intensität.…”

Section: Beurteilung Des Bias-risikosunclassified

Klinische Merkmale und Behandlungen der transitorischen akantholytischen Dermatose (Morbus Grover): ein systematischer Review

Bellinato

Maurelli

Gisondi

et al. 2020

J Deutsche Derma Gesell

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Der Morbus Grover (MG) ist eine juckende akantholytische Erkrankung, die bei Männern mittleren Alters am Rumpf auftritt. Ziel dieser Studie war es, eine Zusammenfassung der klinischen Charakteristika, des Krankheitsverlaufs und der Behandlungen des MG auf Grundlage der besten Evidenz zu erstellen. Entsprechend den PRISMA-Leitlinien wurde ein systematischer Review von Originalarbeiten durchgeführt, die vom 01.01.1970 bis zum 15.08.2019 publiziert wurden. Dabei wurden die klinischen Merkmale und/oder jede Form von Intervention gegen MG bewertet. Insgesamt wurden 263 Artikel erfasst. Davon wurden 116 Originalberichte, welche als relevant erachtet wurden und die Einschlusskriterien erfüllten, in die Analyse eingeschlossen (88 Fallberichte, 26 Fallserien und zwei retrospektive Übersichtsarbeiten). Anhand dieser Artikel wurden 317 Patienten identifiziert. Das Verhältnis von Männern zu Frauen betrug 3,95 und das Durchschnittsalter lag bei 59 Jahren (Bereich 11-92). Typische Läsionen waren juckende Papeln und Papulovesikel, die im Allgemeinen am Rumpf lokalisiert waren, und in 42 % der Fälle innerhalb von einer Woche bis acht Monaten spontan abheilten. Topische Kortikosteroide (TCS) war die häufigste eingesetzte Therapieform (Ansprechrate 70 %), gefolgt von systemischen Retinoiden und Kortikosteroiden mit Ansprechraten von 86 % beziehungsweise 64 %. Den Ergebnissen dieser Untersuchung zufolge scheinen TCS die am häufigsten angewandte Therapiemodalität zu sein, und wir schlagen die TCS als Erstlinientherapie vor. Als Zweitlinienbehandlung kommen systemische Retinoide oder systemische Kortikosteroide in Frage. Summary Grover's disease (GD) is an itchy acantholytic disorder occurring on the trunk of middle-aged men. Based on the best evidence, this study aimed to provide a summary of the clinical characteristics, disease course and treatments of GD. A systematic review was performed according to PRISMA guidelines for original articles published between 01.01.1970-08.15.2019, assessing clinical features and/or any type of intervention for GD. A total of 263 articles were retrieved, and 116 original reports that were deemed relevant and satisfied the inclusion criteria were included in the analysis (88 case reports, 26 case series and two retrospective reviews). From these articles, 317 patients were identified, with a male-to-female ratio of 3.95. The mean age was 59 years (range 11-92). Typical lesions were itchy papules and vesicle-papules, generally Klinische Merkmale und Behandlungen der transitorischen akantholytischen Dermatose (Morbus Grover): ein systematischer Review Clinical features and treatments of transient acantholytic dermatosis (Grover's disease): a systematic review

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Grover's disease (transient acantholytic dermatosis) associated with atopy

Cited by 7 publications

References 9 publications

Grover’s disease in a patient with atopic dermatitis - a case report

Grover’s disease in a patient with atopic dermatitis - a case report

Clinical features and treatments of transient acantholytic dermatosis (Grover’s disease): a systematic review

Klinische Merkmale und Behandlungen der transitorischen akantholytischen Dermatose (Morbus Grover): ein systematischer Review

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